The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity
González-Álvaro, Isidoro (Hospital Universitario de la Princesa (Madrid))
Castrejón, Isabel (Rush University Medical Center)
Carmona, Loreto (Instituto de Salud Musculoesquelética (InMusc))
Casado, Enrique (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García Gómez, M. C. (Hospital Universitari de Bellvitge)
Gómez Centeno, E. (Hospital Clínic i Provincial de Barcelona)
Gómez Vaquero, C. (Hospital Universitari de Bellvitge)
Gratacós, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Larrosa Padro, M. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Sanmartí, Raimon (Hospital Clínic i Provincial de Barcelona)
Tena Marsá, X. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Valls, M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Díaz Torne, César (Institut d'Investigació Biomèdica Sant Pau)
Juanola, Xavier (Hospital Universitari de Bellvitge)
Laiz, Ana (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Δ) of HUPI with Δ in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (ΔGDA-Phy). ΔHUPI correlation with change in all other indices ranged from 0. 387 to 0. 791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using ΔGDA-Phy as gold standard. HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR's.
Grants:	Ministerio de Economía y Competitividad RD16/0012/0011 Ministerio de Economía y Competitividad PI14/00442
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 14 Núm. 4 (april 2019) , p. e0214717, ISSN 1932-6203

DOI: 10.1371/journal.pone.0214717
PMID: 30969989

19 p, 1.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles