Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain : The SEPAR National Registry
Fernández-Fabrellas, Estrella (Consorcio Hospital General Universitario València)
Molina Molina, Maria (Hospital Universitari de Bellvitge)
Soriano, Joan B.. (Hospital Universitario de la Princesa (Madrid))
Rodríguez Portal, José Antonio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Ancochea, Julio (Hospital Universitario de la Princesa (Madrid))
Valenzuela, Claudia (Hospital Universitario de la Princesa (Madrid))
Xaubet, Antoni (Hospital Clínic i Provincial de Barcelona)
Aburto, Myriam (Hospital Galdakao-Usansolo (Bizkaia))
Alfageme, Inmaculada (Hospital Universitario Virgen de Valme (Sevilla, Andalusia))
Bollo de Miguel, Elena (Complejo Asistencial Universitario de León)
Cano, Esteban (Hospital Universitario Lucus Augusti (Lugo))
Casanova Espinosa, Álvaro (Hospital Universitario del Henares (Madrid))
Castillo, Diego (Institut d'Investigació Biomèdica Sant Pau)
Figuerola Mendal, J.A. (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
García Sevila, Raquel (Hospital General Universitario de Alicante (Alacant, País Valencià))
Gaudó Navarro, Javier I. (Hospital Universitario Ramón y Cajal (Madrid))
Gómez-Carrera, Luis (Hospital Universitario La Paz (Madrid))
Saez González, Jesus Miguel (Hospital Universitario de Salamanca)
Herrera Lara, Susana (Hospital Universitari Doctor Peset (València))
Laporta Hernández, Rosalía (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Marín González, M. (Hospital Clínic Universitari (València))
Nieto Barbero, M. Asunción (Hospital Clínico San Carlos (Madrid))
Portillo, Karina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Romero, Ana Dolores (Hospital Universitario Virgen de las Nieves (Granada))
Sánchez Simón-Talero, Rafaela (Hospital Universitario Nuestra Señora del Perpetuo Socorro (Albacete))
Sancho Chust, José N. (Hospital Universitari Sant Joan d'Alacant)
Sellares, Jacobo (Hospital Clínic i Provincial de Barcelona)
Soler-Sempere, Maria J. (Hospital General Universitario de Elche (Alacant))
Sauleda, Jaume (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Tomás López, Laura (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
Villanueva, Manuel Angel (Hospital Universitario San Agustín (Avilés))
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Little is known on the characteristics of patients diagnosed with idiopathic pulmonary fibrosis (IPF) in Spain. We aimed to characterize the demographic and clinical profile of IPF patients included in the IPF National Registry of the Spanish Respiratory Society (SEPAR). This is a prospective, observational, multicentre and nationwide study that involved 608 IPF patients included in the SEPAR IPF Registry up to June 27th, 2017, and who received any treatment for their disease. IPF patients were predominantly males, ex-smokers, and aged in their 70s, similar to other registries. Upon inclusion, mean ± SD predicted forced vital capacity was 77. 6% ± 19. 4, diffusing capacity for carbon monoxide was 48. 5% ± 17. 7, and the 6-min walk distance was 423. 5 m ± 110. 4. The diagnosis was mainly established on results from the high-resolution computed tomography in the proper clinical context (55. 0% of patients), while 21. 2% of patients required invasive procedures (surgical lung biopsy) for definitive diagnosis. Anti-fibrotic treatment was prescribed in 69. 4% of cases, 51. 5% pirfenidone and 17. 9% nintedanib, overall with a good safety profile. The SEPAR IPF Registry should help to further characterize current characteristics and future trends of IPF patients in Spain and compare/pool them with other registries and cohorts.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Anti-fibrotic treatment ; Idiopathic pulmonary fibrosis ; National registry ; SEPAR ; Spain
Published in:	Respiratory Research, Vol. 20 Núm. 1 (17 2019) , p. 127, ISSN 1465-993X

DOI: 10.1186/s12931-019-1084-0
PMID: 31208406

10 p, 1.1 MB

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