Inflammatory biomarkers in Alzheimer's disease plasma
Morgan, Angharad R. (Systems Immunity Research Institute and UK Dementia Research Institute Cardiff, Cardiff University (Regne Unit))
Touchard, Samuel (Systems Immunity Research Institute and UK Dementia Research Institute Cardiff, School of Medicine, Cardiff University (Regne Unit))
Leckey, Claire A. (Cardiff University (Regne Unit))
O'Hagan, Caroline (Cardiff University (Regne Unit))
Nevado-Holgado, Alejo (University of Oxford (Regne Unit))
Barkhof, Frederik (University College London)
Bertram, Lars (Max Planck Institute for Molecular Genetics (Alemanya))
Blin, Olivier (Aix-Marseille University (França))
Bos, Isabelle (Maastricht University (Països Baixos))
Dobricic, Valerija (University of Lübeck (Alemanya))
Engelborghs, Sebastiaan (Institute Born-Bunge (Bèlgica))
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli (Brescia, Itàlia))
Froelich, Lutz (University of Heidelberg (Alemanya))
Gabel, Silvy (Laboratory for Cognitive Neurology (Leuven, Bèlgica))
Johannsen, Peter (Karolinska Institutet (Stockholm, Sweden))
Kettunen, Petronella (University of Gothenburg (Gothenburg, Suècia))
Kłoszewska, Iwona (Medical University of Lodz (Lodz, Poland))
Legido-Quigley, Cristina (Imperial College London)
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau)
Martinez-Lage, Pablo (Fundación CITA-Alzheimer Fundazioa (San Sebastian, Spain))
Mecocci, Patrizia (University of Perugia (Itàlia))
Meersmans, Karen (Laboratory for Cognitive Neurology (Bèlgica))
Molinuevo, José Luis (Universitat Pompeu Fabra)
Peyratout, Gwendoline (Lausanne University Hospital (Suïssa))
Popp, Julius (Hopitaux Universitaires Geneve and Universite de Geneve (Suïssa))
Richardson, Jill (GlaxoSmithKline R&D (Regne Unit))
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Scheltens, Philip (Vrije Universiteit (Països Baixos))
Streffer, Johannes (University of Antwerp)
Soininen, Hikka (University of Eastern Finland)
Tainta, Mikel (Fundación CITA Alzheimer (Sant Sebastià, País Basc))
Teunissen, Charlotte E (University Hospitals Leuven (Bèlgica))
Tsolaki, Magda (AHEPA University Hospital (Grècia))
Vandenberghe, Rik (Amsterdam University Medical Centers (Països Baixos))
Visser, Pieter Jelle (Maastricht University (Països Baixos))
Vos, Stephanie (Maastricht University (Països Baixos))
Wahlund, Lars Olof (Karolinska Institutet (Estocolm, Suècia))
Wallin, Anders (University of Gothenburg Sahlgrenska Academy)
Westwood, Sarah (University of Oxford (Regne Unit))
Zetterberg, Henrik (UK Dementia Research Institute (Londres, Regne Unit))
Lovestone, Simon (University of Oxford (Regne Unit))
Morgan, B. Paul (Cardiff University (Regne Unit))
Bullmore, Edward (University of Cambridge (Regne Unit))
Bhatti, Junaid (University of Cambridge (Regne Unit))
Chamberlain, Samuel J. (University of Cambridge (Regne Unit))
Correia, Marta Morgado (University of Cambridge (Regne Unit))
Crofts, Anna L. (Université de Sherbrooke (Canadà))
Dickinson, Amber (Addenbroke's Hospital (Cambridge, Regne Unit))
Foster, Andy C. (Cambridgeshire and Peterborough NHS Foundation Trust (Regne Unit))
Kitzbichler, Manfred G. (University of Cambridge (Regne Unit))
Knight, Clare (Cambridgeshire and Peterborough NHS Foundation Trust (Regne Unit))
Lynall, Mary-Ellen (University of Cambridge (Regne Unit))
Maurice, Christina (University of Cambridge (Regne Unit))
O'Donnell, Ciara M. (University College London (Regne Unit))
Pointon, Linda J. (University of Cambridge (Regne Unit))
St George Hyslop, Peter (University of Cambridge (Regne Unit))
Turner, Lorinda (University of Cambridge (Regne Unit))
Vertes, Petra E. (University of Cambridge (Regne Unit))
Widmer, Barry (University of Cambridge (Regne Unit))
Williams, Guy (University of Cambridge (Regne Unit))
Cavanagh, Jonathan T. O. (Karolinska Institutet (Estocolm, Suècia))
Deith, Catherine (Southern General Hospital Glasgow (Escòcia))
Farmer, Scott (Bio Med Sciences Inc.(Galveston, Estats Units))
McClean, John (NHS Greater Glasgow and Clyde (Glasgow, Escòcia))
McColl, Alison (College of Medical, Veterinary & Life Sciences (Glasgow, Escòcia))
McPherson, Andrew (Addenbrookes Hospital (Cambridge, Regne Unit))
Scouller, Paul (Addenbrookes Hospital (Cambridge, Regne Unit))
Sutherland, Murray (NHS Greater Glasgow and Clyde (Glasgow, Escòcia))
Boddeke, Erik W.G.M. (Københavns UniversitetThe institution (Copenhaguen, Dinamarca))
Khan, Shahid (GlaxoSmithKline plc. (Regne Unit))
Murphy, Philip Stephen (GlaxoSmithKline plc. (Regne Unit))
Parker, Christine A. (Wellcome Trust (Londres, Regne Unit))
Patel, Jai (GlaxoSmithKline plc. (Regne Unit))
Jones, Declan (Janssen Pharmaceuticals (Titusville, Estats Units))
de Boer, Peter (Janssen Research & Development (Beerse, Bèlgica))
Kemp, John A. (KU Leuven- University Hospital Leuven (Bèlgica))
Drevets, Wayne Curtis (Janssen Research & Development (Beerse, Bèlgica))
Nye, Jeffrey S. (Janssen Research & Development (Beerse, Bèlgica))
Wittenberg, Gayle M. (Janssen Research & Development (Beerse, Bèlgica))
Isaac, John T.R. (Johnson & Johnson (Estats Units))
Bhattacharya, Anindya (Janssen Research & Development (Beerse, Bèlgica))
Carruthers, Niicholas L. (Janssen Research & Development (Beerse, Bèlgica))
Kolb, Hartmuth Christian (Janssen Research & Development (Beerse, Bèlgica))
Pariante, Carmine M. (King's College London (Regne Unit))
Turkheimer, Federico (King's College London (Regne Unit))
Barker, Gareth John (King's College London (Regne Unit))
Byrom, Heidi (King's College London (Regne Unit))
Cash, Diana (King's College London (Regne Unit))
Cattaneo, Annamaria (King's College London (Regne Unit))
Gee, Anthony (King's College London (Regne Unit))
Hastings, Caitlín N.M. (King's College London (Regne Unit))
Mariani, Nicole (King's College London (Regne Unit))
McLaughlin, Anna Patricia (King's College London (Regne Unit))
Mondelli, Valeria (King's College London (Regne Unit))
Nettis, Maria Antonietta (King's College London (Regne Unit))
Nikkheslat, Naghmeh (King's College London (Regne Unit))
Randall, Karen (King's College London (Regne Unit))
Sheridan, Hannah C. (King's College London (Regne Unit))
Simmons, Camilla (King's College London (Regne Unit))
Singh, Nisha (King's College London (Regne Unit))
Van Loo, Victoria (King's College London (Regne Unit))
Vicente-Rodríguez, Marta (King's College London (Regne Unit))
Wood, Tobias (King's College London (Regne Unit))
Worrell, Courtney (King's College London (Regne Unit))
Zajkowska, Zuzanna (King's College London (Regne Unit))
Plath, Niels (H. Lundbeck A/S (Copenhagen, Dinamarca))
Egebjerg, Jan (H. Lundbeck A/S (Copenhagen, Dinamarca))
Eriksson, Hans (H. Lundbeck A/S (Copenhagen, Dinamarca))
Gastambide, Francois (H. Lundbeck A/S (Copenhagen, Dinamarca))
Adams, Karen Husted (H. Lundbeck A/S (Copenhagen, Dinamarca))
Jeggo, Ross D. (H. Lundbeck A/S (Copenhagen, Dinamarca))
Thomsen, Christian (Aalborg University Hospital (Dinamarca))
Pederson, Jan Torleif (H. Lundbeck A/S (Copenhagen, Dinamarca))
Campbell, Brian M. (Lundbeck Research USA Inc. (Deerfield, Estats Units))
Möller, Thomas (Lundbeck Research USA Inc. (Deerfield, Estats Units))
Nelson, Bob (H. Lundbeck A/S (Copenhagen, Dinamarca))
Zorn, Stevin H. (Lundbeck Research USA Inc. (Deerfield, Estats Units))
O'Connor, Jason (University of Texas Hlth Sci Ctr San Antonio(Estats Units))
Attenburrow, Mary Jane (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra))
Baird, Alison (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra))
Benjamin, Jithen (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra))
Clare, Stuart (John Radcliffe Hosp, Oxford Ctr Funct MRI Brain (Oxford, Anglaterra))
Cowen, Philip (University of Oxford (Anglaterra))
Huang, I-Shuo Wade (Kennedy Inst Rheumatol (Oxford, Anglaterra))
Hurley, Samuel A. (University of Wisconsin-Madison (Madison, Estats Units))
Jones, Helen (Warneford Hosp, NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra))
Mada, Francisca (Neurosciences & Neurology)
Nevado-Holgado, Alejo (University of Oxford (Anglaterra))
Oladejo, Akitayo (Metropolitan Hospital Center (New York, Estats Units))
Ribe, Elena (King's College London (Londres, Anglaterra))
Smith, Katy (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra))
Vyas, Anviti (University of Oxford (Oxford, Anglaterra))
Hughes, Zoe (Praxis Precision Medicines (Cambridge, Regne Unit))
Balice-Gordon, Rita (Sanofi S.A. (Gentilly, França))
Duerr, James M. (Pfizer Inc.(New York, Estats Units))
Piro, Justin R. (Pfizer Inc.(New York, Estats Units))
Sporn, Jonathan (Gilgamesh Pharmaceut (New York, Estats Units))
Perry, V. Hugh (University of Southampton. Ctr Biol Sci (Hants, Anglaterra))
Cleal, Madeleine (University of Portsmouth (Anglaterra))
Fryatt, Gemma (University of Southampton. Ctr Biol Sci (Hants, Anglaterra))
Gomez-Nicola, Diego (University of Southampton. Ctr Biol Sci (Hants, Anglaterra))
Mancuso, Renzo (University of Southampton (Anglaterra))
Reynolds, Richard (University of Southampton. Ctr Biol Sci (Hants, Anglaterra))
Harrison, Neil (University fo Sussex (Brighton, Anglaterra))
Cercignani, Mara (University fo Sussex (Brighton, Anglaterra))
Clarke, Charlotte L. (University of Sussex (Brighton, Regne Unit))
Hoskins, Elizabeth (Sussex Partnership NHS Foundation Trust (Worthing, Regne Unit))
Kohn, Charmaine (Sussex Partnership NHS Foundation Trust (Worthing, Regne Unit))
Murray, Rosemary (Addenbrookes Hospital (Cambridge, Regne Unit))
Wilcock, Lauren (Sussex Partnership NHS Fdn Trust (Hove, Anglaterra))
Wlazly, Dominika (Brighton and Sussex University Hospitals NHS Trust (Sussex, Anglaterra))
Mount, Howard T.J. (University of Toronto (Toronto, Canadà))
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers. A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed. Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APOε4 adjusted, optimally differentiated AD and CTL (AUC: 0. 79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0. 74). These models replicated in an independent cohort (EMIF; AUC 0. 81 and 0. 67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0. 71). Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 776-787, ISSN 1552-5279

DOI: 10.1016/j.jalz.2019.03.007
PMID: 31047856

12 p, 1.1 MB

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