Minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis : predictive model based on machine learning
Queiro, R. (Universidad de Oviedo)
Seoane-Mato, D. (Sociedad Española de Reumatología)
Laiz, Ana (Institut d'Investigació Biomèdica Sant Pau)
Agirregoikoa, Eva Galíndez (Hospital de Basurto (Bilbao, Biscaia))
Montilla, C. (Hospital Universitario de Salamanca)
Park, Hye-Sang (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Pinto-Tasende, J.A. (Complejo Hospitalario Universitario de A Coruña)
Bethencourt Baute, Juan José (Hospital Universitario de Canarias (La Laguna))
Ibáñez, B.J. (Hospital Universitario 12 de Octubre)
Toniolo, E. (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
Ramírez, Julio (Hospital Clínic i Provincial de Barcelona)
García, A.S. (Universidad Autónoma de Madrid)
Cañete, J. D.
Juanola, X.
Fiter, J.
Gratacós, J.
Rodriguez-Moreno, J.
Rosa, J.N.
Martín, A.L.
García, A.B.
Segura, P.C.
López-Ferrer, Anna (Institut d'Investigació Biomèdica Sant Pau)
Barrio, S.P.
Plata Izquierdo, A.J.
Bustabad, S.
Guimerá Martín-Neda, F.J.
Capdevilla, E.F.
Díaz, R.R.
Cuervo, A.
Gibert, M.A.
Larraz, P.T.
de la Morena Barrio, I.
Lanza, L.P.
Sanchís, D.B.
Mesquida, C.M.
Murillo, C.
Moreno Ramos, M.J.
Beteta, M.D.
Guillén, P.S.P.
Oliveira, L.L.
Marco, T.N.
Cebrián, L.
De la Cueva, Pablo
Steiner, M.
Muñoz-Fernández, S.
Garrido, R.V.
León, M.
Rubio, E.
Jiménez, A.M.
Fernández-Freire, L. R.
Luezas, J.M.
Sánchez-González, M.D.
Muñoz, C.S.
Senabre, J.M.
Rosas, J.C.
Soler, G.S.
Mataix Díaz, F.J.
Nieto-González, J.C.
González, C.
Ovalles Bonilla, J.G.
Rodríguez, O.B.
Medina, F.J.N.
Luján, D.
Ruiz Montesino, M.D.
Carrizosa Esquivel, A.M.
Fernández-Carballido, C.
Martínez-Vidal, M.P.
Fernández, L.G.
Jovani, V.
Alameda, R.C.
Sabater, S.G.
Romero, I.B.
Urruticoechea-Arana, A.
Torres, M.S.
Almodóvar, Raquel
López Estebaranz, J.L.
López Montilla, M.D.
García-Nieto, A.V.
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Very few data are available on predictors of minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis (PsA). Such data are crucial, since the therapeutic measures used to change the adverse course of PsA are more likely to succeed if we intervene early. In the present study, we used predictive models based on machine learning to detect variables associated with achieving MDA in patients with recent-onset PsA. We performed a multicenter observational prospective study (2-year follow-up, regular annual visits). The study population comprised patients aged ≥18 years who fulfilled the CASPAR criteria and less than 2 years since the onset of symptoms. The dataset contained data for the independent variables from the baseline visit and from follow-up visit number 1. These were matched with the outcome measures from follow-up visits 1 and 2, respectively. We trained a random forest-type machine learning algorithm to analyze the association between the outcome measure and the variables selected in the bivariate analysis. In order to understand how the model uses the variables to make its predictions, we applied the SHAP technique. We used a confusion matrix to visualize the performance of the model. The sample comprised 158 patients. 55. 5% and 58. 3% of the patients had MDA at the first and second follow-up visit, respectively. In our model, the variables with the greatest predictive ability were global pain, impact of the disease (PsAID), patient global assessment of disease, and physical function (HAQ-Disability Index). The percentage of hits in the confusion matrix was 85. 94%. A key objective in the management of PsA should be control of pain, which is not always associated with inflammatory burden, and the establishment of measures to better control the various domains of PsA.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Machine learning ; Minimal disease activity ; Predictive model ; Recent-onset psoriatic arthritis
Publicat a:	Arthritis research & therapy, Vol. 24 Núm. 1 (december 2022) , p. 153, ISSN 1478-6362

DOI: 10.1186/s13075-022-02838-2
PMID: 35751091

9 p, 1.1 MB

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