Impact of hepatitis D reflex testing on the future disease burden : A modelling analysis
Buti, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Domínguez-Hernández, Raquel (Pharmacoeconomics & Outcomes Research Iberia)
Palom, Adriana (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Esteban, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Casado, Miguel Ángel (Pharmacoeconomics & Outcomes Research Iberia)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Chronic hepatitis D (CHD) is a severe form of viral hepatitis that leads to liver cirrhosis and hepatocellular carcinoma. CHD is underdiagnosed, and this study aimed to assess the impact of hepatitis D reflex testing in HBsAg-positive individuals in Spain over the next 8 years. Two scenarios were compared: the current situation (7. 6% of HBsAg-positive patients tested for anti-HDV) and reflex testing for all positive samples. A decision tree model was designed to simulate the CHD care cascade. Implementing reflex testing would increase anti-HDV detection to 5498 cases and HDV-RNA to 3225 cases. Additionally, 2128 more patients would receive treatment, with 213 achieving undetectable HDV-RNA levels. The cost per anti-HDV case detected would be €132. In the median time of the analysis, liver complications (decompensated cirrhosis, HCC and liver-related deaths) would be reduced by 35%-38%, implying an estimated cost savings of 36 million euros associated with the management of such complications. By 2030, implementing anti-HDV reflex testing would reduce the clinical and economic burden of CHD by 35%-38%.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Burden ; Hepatitis D virus (HDV) ; Reflex testing ; Screening
Published in:	Liver International, Vol. 43 Núm. 12 (december 2023) , p. 2611-2614, ISSN 1478-3231

DOI: 10.1111/liv.15776

4 p, 534.8 KB

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