Differential Hypothalamic-pituitary-adrenal Response to Stress among Rat Strains : Methodological Considerations and Relevance for Neuropsychiat-ric Research
Armario Garcia, Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Belda Poyato, Francisco Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Gagliano, Humberto Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Fuentes, Silvia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Molina Molina, Patricia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Serrano Garcia, Sara (Universitat Autònoma de Barcelona. Institut de Neurociències)
Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2023
Abstract:	The hormones of the hypothalamic-pituitary-adrenal (HPA) axis, particularly glucocorti-coids (GCs), play a critical role in the behavioral and physiological consequences of exposure to stress. For this reason, numerous studies have described differences in HPA function between different rodent strains/lines obtained by genetic selection of certain characteristics not directly related to the HPA axis. These studies have demonstrated a complex and poorly understood relationship between HPA function and certain relevant behavioral characteristics. The present review first remarks important methodological considerations regarding the evaluation and interpretation of resting and stress levels of HPA hormones. Then, it presents works in which differences in HPA function between Lewis and Fischer rats were explored as a model for how to approach other strain comparisons. After that, differences in the HPA axis between classical strain pairs (e. g. High and Low anxiety rats, Roman high-and low-avoidance, Wistar Kyoto versus Spontaneously Hypertensive or other strains, Flinder Sensitive and Flinder Resistant lines) are described. Finally, after discussing the relationship between HPA differences and relevant behavioral traits (anxiety-like and depression-like behavior and coping style), an example for main methodological and interpretative concerns and how to test strain differences is offered.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca SGR2017-457 Agencia Estatal de Investigación SAF2017-83430-R Agencia Estatal de Investigación PID2020-11884RB-I00
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Ressenya ; recerca ; Versió acceptada per publicar
Published in:	Current neuropharmacology, Vol. 21 Núm. 9 (2023) , p. 1906-1923, ISSN 1875-6190

DOI: 10.2174/1570159X21666221129102852
PMID: 36453492

30 p, 744.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
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Articles > Published articles
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