Graded photochemical spinal cord injury results in chronic hyperalgesia and depression-like behaviour but no anxiety exacerbation in female BALB/c mice
Boadas Vaello, Pere (Universitat de Girona. Departament de Ciències Mèdiques)
Homs i Avila, Judit (Universitat de Girona. Departament de Ciències Mèdiques)
Portero Tresserra, Marta (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Álvarez-Pérez, Beltrán (Universitat de Girona. Departament de Ciències Mèdiques)
Deulofeu, Meritxell (Universitat de Girona. Departament de Ciències Mèdiques)
Verdú Navarro, Enrique (Universitat de Girona. Departament de Ciències Mèdiques)

Data:	2018
Resum:	Neuropathic pain (NP) is present in 40-to-50% of spinal cord injured patients. It tends to chronicity and correlates with lower quality-of-life. Moreover, the role of NP in the eventual exacerbation of anxiety- and depression-like behaviours during its development and chronification in genetically susceptible individuals remains unclear. Thus, although solely few animal models are available, new specific models are needed to complete the array of chances to assay new therapeutic strategies with the aim of treating chronic NT and its associated mood disorders. The present study was conceived to evaluate hyperalgesic responses and anxiety- and depression-like behaviours after graded photochemical spinal cord injury (SCI) up to chronic phase. BALB/c strain was used: it expresses a phenotype characterized by high innate anxiety levels, allowing to elucidate whether NP may exacerbate mood disorders at SCI chronic phase. After different photoinduction-times on exposed spinal cord, the mice developed a graded chronic hyperalgesia with minor to non-existent motor dysfunction. Behavioural data suggest that whilst hyperalgesia associated to SCI does not exacerbate BALB/c anxiety-like behaviours, it may result in depression-like behaviour at SCI chronic phase. Our study demonstrates that chronic central hyperalgesia may exacerbate despair-like behaviour at the SCI chronic phase in a mouse model of high anxiety-related behaviour. This implies that photochemical-SCI may be a suitable model to study the comorbidity between chronic NP and mood disorders.
Nota:	Altres ajuts: RecerCaixa 2010 (Obra Social La Caixa-ACUP); Vicerectorat de la Universitat de Girona (Sing12/17 and MPCUdG2016/087)
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Behavioural disturbances ; Immunohistochemistry ; Mice ; Neuropathic pain ; Photochemical spinal cord injury
Publicat a:	Neuroscience Letters, Vol. 664 (2018) , p. 98-106, ISSN 1872-7972

DOI: 10.1016/j.neulet.2017.11.007
PMID: 29126777

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