Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex
Portero Tresserra, Marta (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida)
Gracia-Rubio, Irene (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida)
Cantacorps, Lídia (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida)
Pozo, Oscar J (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya))
Gómez-Gómez, Alejandro (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya))
Pastor, Antoni (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya))
López-Arnau, Raúl (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica)
De La Torre, Rafael (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya))
Valverde, Olga (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida)

Date:	2018
Description:	14 pàg.
Abstract:	Childhood adversity is associated with an increased risk of mood, anxiety and substance use disorders. Maternal separation is a reliable rodent model of early life adversity that leads to depression-like symptoms, which may increase the vulnerability to alcohol consumption during adolescence. However, the specific alterations in the pattern of alcohol consumption induced by maternal separation and the underlying molecular mechanisms are still unclear. The purpose of this study is to evaluate the long-term effects of maternal separation with early weaning (MSEW) on emotional and social behaviour, alcohol rewarding properties, and alcohol consumption, abstinence and relapse in adolescent male C57BL/6 mice. In addition, endocannabinoid and monoamine levels were analysed in discrete brain areas. Results showed that MSEW mice presented emotional alterations related to depressive-like behaviour and modified endocannabinoid levels in the striatum and the prefrontal cortex. MSEW mice also showed impairments in alcohol-induced conditioned place preference and higher alcohol intake in a model of binge drinking. Moreover, MSEW animals displayed a higher propensity to relapse in the two-bottle choice paradigm following a period of alcohol abstinence associated with reduced monoamine levels in the striatum. Such results indicate that exposure to early life stress increased the vulnerability to alcohol binge-drinking during adolescence, which may be partially explained by decreased sensitivity to alcohol rewarding properties and the ability to potentiate alcohol intake following a period of abstinence.
Grants:	Ministerio de Ciencia e Innovación SAF2016-75966-R Instituto de Salud Carlos III CPII16/ 00027 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-680
Note:	Altres ajuts: This study was supported by Plan Nacional sobre Drogas (2014/020) i UE Medbioinformatic project (grant number 634143).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió de l'autor
Published in:	European neuropsychopharmacology, Vol. 28 Núm. 4 (2018) , p. 499-512, ISSN 1873-7862

DOI: 10.1016/j.euroneuro.2018.02.003
PMID: 29478745

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