Anti-inflammatory Cotton Fabrics and Silica Nanoparticles with Potential Topical Medical Applications
Li, Hao (Universitat Autònoma de Barcelona. Departament de Química)
Granados Toda, Albert (Universitat Autònoma de Barcelona. Departament de Química)
Fernandez, Ester (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Pleixats i Rovira, Roser (Universitat Autònoma de Barcelona. Departament de Química)
Vallribera Massó, Adelina (Universitat Autònoma de Barcelona. Departament de Química)

Date:	2020
Abstract:	The preparation of functional cotton fabrics and silica nanoparticles by direct covalent linking of nonsteroidal anti-inflammatory drugs (salicylic acid, ibuprofen, and diclofenac) through an amide group is reported. Moreover, the coating of cotton fabrics with silica nanoparticles functionalized with such antiinflamatory agents is found to increase the roughness of the surface, providing hydrophobicity to the modified fabrics. This property is enhanced by the addition of fluorinated alkyl silane in the co-condensation process to form the coating solution. Characterization of the functionalized nanoparticles and cotton textiles is accomplished by microscopic and spectroscopic techniques. The treatment of functionalized nanoparticles and cotton fabrics with model proteases and leukocytes from animal origin results in the in situ release of the drug by the selective enzymatic cleavage of the amide bond. Topical cutaneous applications in wound dressings and cream formulations for the acceleration of wound healing are envisaged.
Grants:	Ministerio de Economía y Competitividad CTQ2014-53662-P Ministerio de Economía y Competitividad CTQ2016-81797-REDC Agencia Estatal de Investigación RTI2018-097853-B-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-0465
Note:	Altres ajuts: Universitat Autònoma de Barcelona predoctoral scholarships
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Functional coatings ; Medical applications ; Nanoparticles ; Silicas ; Superhydrophobic surfaces
Published in:	ACS applied materials & interfaces, Vol. 12, Issue 23 (June 2020) , p. 25658-25675, ISSN 1944-8252

DOI: 10.1021/acsami.0c06629

Postprint 15 p, 1.5 MB

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