Epidemiology of gestational diabetes mellitus according to IADPSG/WHO 2013 criteria among obese pregnant women in Europe
Egan, Aoife M. (National University of Ireland)
Vellinga, Akke (National University of Ireland)
Harreiter, Jürgen (Medical University of Vienna)
Simmons, David (Western Sydney University)
Desoye, Gernot (Medizinische Universitaet Graz)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Adelantado, Juan M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Devlieger, Roland (University Hospitals Leuven (Bèlgica))
Van Assche, Andre (University Hospitals Leuven (Bèlgica))
Galjaard, Sander (University Medical Centre Rotterdam)
Damm, Peter (University of Copenhagen)
Mathiesen, Elisabeth R. (University of Copenhagen)
Jensen, DorteM. (University of Southern Denmark)
Andersen, Lise-Lotte (University of Southern Denmark)
Lapolla, Annuziata (Universita Degli Studi di Padova)
Dalfrà, MariaG. (Universita Degli Studi di Padova)
Bertolotto, Alessandra (Azienda Ospedaliero-Universitaria Pisana)
Mantaj, Urszula (Poznan University of Medical Sciences)
Wender-Ozegowska, Ewa (Poznan University of Medical Sciences)
Zawiejska, Agnieszka (Poznan University of Medical Sciences)
Hill, David (Recherche en Santé Lawson SA)
Jelsma, Judith G.M. (VU University Medical Centre)
Snoek, Frank J. (VU University Medical Centre and Medical Psychology AMC)
Worda, Christof (Medical University of Vienna)
Bancher-Todesca, Dagmar (Medical University of Vienna)
van Poppel, M.N.M. (University of Graz)
Kautzky-Willer, Alexandra (Medical University of Vienna)
Dunne, Fidelma P. (National University of Ireland)
Universitat Autònoma de Barcelona

Data:	2017
Resum:	Accurate prevalence estimates for gestational diabetes mellitus (GDM) among pregnant women in Europe are lacking owing to the use of a multitude of diagnostic criteria and screening strategies in both high-risk women and the general pregnant population. Our aims were to report important risk factors for GDM development and calculate the prevalence of GDM in a cohort of women with BMI ≥29 kg/m across 11 centres in Europe using the International Association of the Diabetes and Pregnancy Study Groups (IADPSG)/WHO 2013 diagnostic criteria. Pregnant women (n = 1023, 86. 3% European ethnicity) with a BMI ≥29. 0 kg/m enrolled into the Vitamin D and Lifestyle Intervention for GDM Prevention (DALI) pilot, lifestyle and vitamin D studies of this pan-European multicentre trial, attended for an OGTT during pregnancy. Demographic, anthropometric and metabolic data were collected at enrolment and throughout pregnancy. GDM was diagnosed using IADPSG/WHO 2013 criteria. GDM treatment followed local policies. The number of women recruited per country ranged from 80 to 217, and the dropout rate was 7. 1%. Overall, 39% of women developed GDM during pregnancy, with no significant differences in prevalence across countries. The prevalence of GDM was high (24%; 242/1023) in early pregnancy. Despite interventions used in the DALI study, a further 14% (94/672) had developed GDM when tested at mid gestation (24-28 weeks) and 13% (59/476) of the remaining cohort at late gestation (35-37 weeks). Demographics and lifestyle factors were similar at baseline between women with GDM and those who maintained normal glucose tolerance. Previous GDM (16. 5% vs 7. 9%, p = 0. 002), congenital malformations (6. 4% vs 3. 3%, p = 0. 045) and a baby with macrosomia (31. 4% vs 17. 9%, p = 0. 001) were reported more frequently in those who developed GDM. Significant anthropometric and metabolic differences were already present in early pregnancy between women who developed GDM and those who did not. The prevalence of GDM diagnosed by the IADPSG/WHO 2013 GDM criteria in European pregnant women with a BMI ≥29. 0 kg/m is substantial, and poses a significant health burden to these pregnancies and to the future health of the mother and her offspring. Uniform criteria for GDM diagnosis, supported by robust evidence for the benefits of treatment, are urgently needed to guide modern GDM screening and treatment strategies.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Clinical diabetes ; Clinical science and care ; Epidemiology ; Healthcare delivery ; Pregnancy ; Weight regulation and obesity
Publicat a:	Diabetologia, Vol. 60 Núm. 10 (january 2017) , p. 1913-1921, ISSN 1432-0428

DOI: 10.1007/s00125-017-4353-9
PMID: 28702810

9 p, 401.7 KB

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