Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD
Llorens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Barba, Maria (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Torralbas Ortega, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)
Armario Garcia, Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Gagliano, Humberto Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Urraca Camps, Lara (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Pujol, Susana (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Montalvo Aguirrezabala, Itziar (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Gracia Liso, Rebeca (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Polo, Diana (Hospital Sant Joan de Déu (Manresa))
Gonzalez Riesco, Laura (Hospital Sant Joan de Déu (Manresa))
Matalí, Josep Lluís (Institut de Recerca Sant Joan de Déu)
Palao, Diego (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Pàmias Massana, Montserrat (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Labad, Javier (Consorci Sanitari del Maresme)

Additional title:	Relación entre las concentraciones de cortisol capilar y el funcionamiento cognitivo en adolescentes con TDAH
Date:	2023
Abstract:	Background: Our study aimed to explore whether the hair cortisol concentration (HCC), a measure of long-term cortisol output, is associated with poorer cognitive functioning in adolescents with attention deficit and hyperactivity disorder (ADHD). We further aimed to test the potential moderating effects of sex and childhood maltreatment. Methods: In this cross-sectional study, fifty-three adolescents with ADHD were studied. The ADHD Rating Scale (ADHD-RS) and Childhood Trauma Questionnaire (CTQ) were administered. Seven cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were administered, and two cognitive factors (attention and memory and executive functioning) were identified by confirmatory factor analysis. A 3-cm hair sample from the posterior vertex region of the head was obtained. HCCs were determined by a high-sensitivity enzyme immunoassay kit. Multiple linear regression analyses were used to explore the association between HCCs and either cognitive performance or ADHD severity while adjusting for sex, childhood maltreatment and the ADHD-RS total score. Results: Sex moderated the relationship between HCCs and attention/memory confirmatory factor analysis (CFA) scores, with better performance in boys with higher HCCs. HCCs were not associated with executive functioning or ADHD symptoms. Childhood maltreatment was associated with inattention symptoms in adolescents with ADHD. Conclusions: Our study suggests that HCCs are positively associated with attention and memory performance in adolescents with ADHD, with a moderating effect of sex (the relationship is strongest in boys).
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1412
Note:	This research was supported by the CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB029), Instituto de Salud Carlos III, and Spanish Ministry of Science and Innovation.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Castellà
Document:	Article ; recerca ; Versió publicada
Subject:	Cortisol ; Stress ; ADHD ; Cognition ; Childhood trauma ; Sex ; TDAH ; Cognición ; Trauma infantil ; Sexo
Published in:	European Journal of Psychotraumatology, Vol. 14 Núm. 2 (2023) , art. 2281752, ISSN 2000-8066

DOI: 10.1080/20008066.2023.2281752
PMID: 38154075

12 p, 1.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles