Physiological and behavioural consequences of long-term moderate treadmill exercise
F. Lalanza, Jaume (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Sanchez-Roige, Sandra (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Gagliano, Humberto Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències)
Fuentes, Silvia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Bayod, Sergi (Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas)
Camins, Antoni (Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas)
Pallàs, Mercè (Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas)
Armario Garcia, Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències)
Escorihuela, Rosa M. (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Date:	2012
Abstract:	The benefits of long-term moderate exercise for health are widely accepted in humans, but few animal studies have been undertaken to characterize the effects of such activity on emotionality and responsiveness to stress. The present study describes the effects of long-term moderate forced treadmill training (36 weeks) on exploratory activity, anxiety-like behaviour, and the resting or stress levels of some physiological variables, including pituitary-adrenal (PA) hormones. Five-week-old male Sprague-Dawley rats were trained on the treadmill (TM) for 36 weeks, using a more moderate training (12. m/min, 30. min/day, 4-5 days/week) than that currently used in the literature. Two groups were used as controls: a non-handled sedentary (SED) group, receiving no manipulation, and a control (CON) group exposed to a stationary treadmill for the same amount of time as the TM group. In accordance with literature data, TM rats showed lower resting levels of glucose, triglycerides and cholesterol than the other two groups. The TM and CON groups both showed higher ambulation than the SED group in some behavioural tests, without evidence for altered anxiety. Resting levels of adrenocorticotropin (ACTH) and corticosterone did not differ among the groups, but a reduced ACTH response to both a novel environment (mild stressor) and an active escape-avoidance task (severe stressor) was observed in TM rats, whereas changes in corticosterone were modest. The results support the view that the physiological consequences of long-term moderate training are beneficial, including reduced PA responsiveness to stress, even though exercise training did not affect anxiety-like behaviour. © 2012 Elsevier Ltd.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca FI-DGR 2011 Agència de Gestió d'Ajuts Universitaris i de Recerca SGR-2009-16 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-00893 Ministerio de Ciencia e Innovación PSI2008-06417-C03-01 Ministerio de Ciencia e Innovación SAF2009-13093 Ministerio de Ciencia e Innovación SAF2008-01175 Instituto de Salud Carlos III DPS2008-06998-C01 Ministerio de Sanidad y Consumo RD06/0001/0015
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Long-term moderate exercise ; Treadmill ; Hole board ; Elevated plus maze ; Open field ; Stress responsiveness ; ACTH ; Corticosterone ; Metabolism
Published in:	Psychoneuroendocrinology, Vol. 37 Núm. 11 (november 2012) , p. 1745-1754, ISSN 1873-3360

DOI: 10.1016/j.psyneuen.2012.03.008

40 p, 483.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles