Impact of 3-monthly vitamin D supplementation plus exercise on survival after surgery for osteoporotic hip fracture in adult patients over 50 years : A pragmatic randomized, partially blinded, controlled trial
Laiz, Ana (Institut d'Investigació Biomèdica Sant Pau)
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau)
Marin, A. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Longobardi, V. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
de Caso, Julio (Institut d'Investigació Biomèdica Sant Pau)
Farrerons, J. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Casademont i Pou, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Fecha:	2017
Resumen:	To determine whether 3-monthly supplementation of an oral vitamin D widely used in Spain (calcifediol) plus daily exercise could influence survival at one and four years after surgery for osteoporotic hip fracture. A pragmatic, randomized, partially single-blind placebo-controlled study. Patients admitted to a tertiary university hospital for acute hip fracture. 675 healthy adult patients undergoing surgery for osteoporotic hip fracture were recruited from January 2004 to December 2007. Patients were randomized to receive either 3-monthly oral doses of 3 mg calcifediol (Hidroferol Choque®) or placebo in the 12 months postsurgery. Patients who received calcifediol were also given an exercise programme. The placebo group received standard health recommendations only. The primary endpoint was survival at 1 year and at 4 year follow-up. We also recorded new fractures, medical complications and anti-osteoporotic treatment compliance. We included a total of 88 patients, aged 62 to 99 years. Mean age was 82 years and 88. 6% were women. At 12 months, 10 (11. 3%) patients had died, 9 of them, from the non-intervention group. At 4 years after surgery, 20 (22. 7%) had died, 3 (3. 4%) from the intervention group and 17 (19. 3%) from the non-intervention group. At this time, survival curve analysis showed 93% survival in the intervention group and 62% in the non-intervention group (p=0. 001). At 12-month follow up, there were 18 new fractures, 9 in each group. The non-intervention group had more medical complications, with significant differences at visit 2 (p = 0. 04) and 3 (p = 0. 02) but not at visit 4 (p = 0. 18). No significant differences between groups were found regarding treatment compliance. 3-monthly, oral supplements of 3 mg calcifediol plus daily exercise improved survival at one-year and four-year follow up after surgery for an osteoporotic hip fracture.
Ayudas:	Ministerio de Ciencia e Innovación PI11/01175 Ministerio de Economía y Competitividad PI14/01036
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Exercise ; Hip fracture ; Osteoporosis ; Survival ; Vitamin D
Publicado en:	Journal of Nutrition, Health and Aging, Vol. 21 Núm. 4 (january 2017) , p. 413-420, ISSN 1760-4788

DOI: 10.1007/s12603-016-0773-3
PMID: 28346568

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