Cord Blood Units with High CD3+ Cell Counts Predict Early Lymphocyte Recovery After In Vivo T Cell-Depleted Single Cord Blood Transplantation
Castillo, N. (Banc de Sang i Teixits)
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau)
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron)
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau)
Barba, Pere (Hospital Universitari Vall d'Hebron)
Ferrá, Christelle (Institut Català d'Oncologia)
Canals, Carme (Banc de Sang i Teixits)
Elorza, Izaskun (Hospital Universitari Vall d'Hebron)
Olivé, Teresa (Hospital Universitari Vall d'Hebron)
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau)
Valcárcel, David (Hospital Universitari Vall d'Hebron)
Querol, Sergio (Banc de Sang i Teixits)
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	Although high absolute lymphocyte count (ALC) early after transplantation is a simple surrogate for immune reconstitution, few studies to date have established the predictive factors for ALC after umbilical cord blood transplantation (UCBT). We retrospectively studied the factors associated with early lymphocyte recovery and the impact of the ALC on day +42 (ALC42) of ≥300 × 10/L on outcomes in 210 consecutive pediatric and adult patients (112 males; median age, 15 years; range, 0. 3 to 60 years; interquartile range, 4 to 36 years) who underwent myeloablative in vivo T cell-depleted single UCBT between 2005 and 2014 for malignant and nonmalignant disorders. In a logistic multivariate regression model, factors favoring a higher ALC42 were higher infused CD3 cell dose (odds ratio [OR], 2. 7; 95% CI, 1. 4 to 5. 2; P =. 004), lower antithymocyte globulin dose (OR, 2. 3; 95% CI, 1. 2 to 4. 5; P =. 01), and better HLA match (OR, 2. 1; 95% CI, 1. 1 to 4. 1; P =. 03). In multivariate analysis, lower ALC42 was associated with higher nonrelapse mortality (hazard ratio [HR], 1. 76; 95% CI, 1. 34 to 2. 32; P =. 001), whereas a higher ALC42 was associated with better disease-free survival (HR, 2. 03; 95% CI, 1. 15 to 3. 6; P <. 001) and overall survival (HR, 2. 03; 95% CI, 1. 17 to 3. 6; P <. 001). Our study suggests that the selection of better HLA-matched cord blood units containing higher CD3 cell counts and the use of conditioning regimens with lower ATG doses could improve immune reconstitution after UCBT.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Lymphocyte recovery ; T cell depletion ; Umbilical cord blood transplantation
Published in:	Biology of blood and marrow transplantation, Vol. 22 Núm. 6 (january 2016) , p. 1073-1079, ISSN 1523-6536

DOI: 10.1016/j.bbmt.2016.03.009
PMID: 27038860

7 p, 480.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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