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Maternal Stress, Anxiety, Well-Being, and Sleep Quality in Pregnant Women throughout Gestation
Pascal, Rosalia (Institut de Recerca Sant Joan de Déu)
Casas, Irene (Institut D'investigacions Biomèdiques August Pi Sunyer)
Genero, Mariona (Institut de Recerca Sant Joan de Déu)
Nakaki, Ayako (Institut D'investigacions Biomèdiques August Pi Sunyer)
Youssef, Lina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Larroya, Marta (Institut D'investigacions Biomèdiques August Pi Sunyer)
Benitez, Leticia (Institut D'investigacions Biomèdiques August Pi Sunyer)
Gomez, Yvan (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Martínez-Àran, Anabel (Universitat de Barcelona)
Morilla, Ivette (Universitat de Barcelona)
Oller-Guzmán, Teresa M. (Instituto esMindfulness)
Martín-Asuero, Andrés (Instituto esMindfulness)
Vieta, Eduard (Department of Psychiatry and Psychology. University of Barcelona)
Crispi, Fàtima (Center for Biomedical Network Research on Rare Diseases)
Gratacos, Eduard (Center for Biomedical Network Research on Rare Diseases)
Gomez-Roig, María Dolores (Institut de Recerca Sant Joan de Déu)
Crovetto, Francesca (Institut de Recerca Sant Joan de Déu)
Universitat Autònoma de Barcelona

Date: 2023
Abstract: Background: Maternal stress, anxiety, well-being, and sleep quality during pregnancy have been described as influencing factors during pregnancy. Aim: We aimed to describe maternal stress, anxiety, well-being, and sleep quality in pregnant women throughout gestation and their related factors. Methods: A prospective study including pregnant women attending BCNatal, in Barcelona, Spain (n = 630). Maternal stress and anxiety were assessed by the Perceived Stress Scale (PSS) and State-Trait Anxiety Inventory (STAI)-validated questionnaires. Maternal well-being was assessed using the World Health Organization Well-Being Index Questionnaire (WHO-5), and sleep quality was assessed using the Pittsburgh Sleep Quality Index Questionnaire (PSQI). All questionnaires were obtained twice during the second and third trimester of pregnancy. A multivariate analysis was conducted to assess factors related to higher maternal stress and anxiety and worse well-being and sleep quality. Results: High levels of maternal stress were reported in 23. 1% of participants at the end of pregnancy, with maternal age <40 years (OR 2. 02; 95% CI 1. 08-3. 81, p = 0. 03), non-white ethnicity (OR 2. 09; 95% CI 1. 19-4. 02, p = 0. 01), and non-university studies (OR 1. 86; 95% CI 1. 08-3. 19, p = 0. 02) being the parameters mostly associated with it. A total of 20. 7% of women had high levels of anxiety in the third trimester and the presence of psychiatric disorders (OR 3. 62; 95% CI 1. 34-9. 78, p = 0. 01) and non-university studies (OR 1. 70; 95% CI 1. 11-2. 59, p = 0. 01) provided a significant contribution to high anxiety at multivariate analysis. Poor maternal well-being was observed in 26. 5% of women and a significant contribution was provided by the presence of psychiatric disorders (OR 2. 96; 95% CI 1. 07-8. 25, p = 0. 04) and non-university studies (OR 1. 74; 95% CI 1. 10-2. 74, p = 0. 02). Finally, less sleep quality was observed at the end of pregnancy (p < 0. 001), with 81. 1% of women reporting poor sleep quality. Conclusion: Maternal stress and anxiety, compromised maternal well-being, and sleep quality disturbances are prevalent throughout pregnancy. Anxiety and compromised sleep quality may increase over gestation. The screening of these conditions at different stages of pregnancy and awareness of the associated risk factors can help to identify women at potential risk.
Grants: Agència de Gestió d'Ajuts Universitaris i de Recerca 2021SGR01422
Instituto de Salud Carlos III CM21/00058
Instituto de Salud Carlos III INT21/00027
"la Caixa" Foundation LCF/PR/GN14/10270005
"la Caixa" Foundation LCF/PR/GN18/10310003
Note: This study was partially funded by the "LaCaixa" Foundation under grant agreements LCF/PR/GN14/10270005 and LCF/PR/GN18/10310003, the CEREBRA Foundation for the Brain Injured Child (Carmarthen, Wales, UK) and the Departament de Recerca i Universitats de la Generalitat de Catalunya 2021-SGR-01422. LB and FC have received funding from the Instituto de Salud Carlos III (ISCIII) through the projects CM21/00058 and INT21/00027 which are co-funded by the European Union. Funders played no role in the study's design, data collection, data analysis, data interpretation, or the writing of the manuscript.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Subject: Mental stress ; Anxiety ; Well-being ; Sleep quality ; Pregnancy
Published in: Journal of clinical medicine, Vol. 12 Núm. 23 (december 2023) , p. 7333, ISSN 2077-0383

DOI: 10.3390/jcm12237333
PMID: 38068385


16 p, 672.8 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
Articles > Research articles
Articles > Published articles

 Record created 2024-03-01, last modified 2024-05-04



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