The relapsed acute lymphoblastic leukemia network (ReALLNet) : a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
Velasco, Pablo (Hospital Universitari Vall d'Hebron)
Bautista, Francisco (Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands)
Rubio, Alba (Hospital Infantil Universitario Niño Jesús (Madrid))
Aguilar, Yurena (Hospital Miguel Servet Hospital)
Rives, Susana (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Dapena, Jose L (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Pérez, Antonio (Universidad Autónoma de Madrid)
Ramirez, Manuel (Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús)
Saiz-Ladera, Cristina (Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús)
Izquierdo, Elisa (Hospital Universitario La Paz (Madrid))
Escudero, Adela (Hospital Universitario La Paz (Madrid))
Camós, Mireia (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Vega-García, Nerea (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Ortega, Margarita (Vall d'Hebron Institut d'Oncologia)
Hidalgo-Gómez, Gloria (Vall d'Hebron Institut d'Oncologia)
Palacio, Carlos (Vall d'Hebron Institut d'Oncologia)
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Montero, Joan (Universitat de Barcelona)
Romecín, Paola A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Zazo, Santiago (Universidad Politécnica de Madrid)
Alvarez, Federico (Universidad Politécnica de Madrid)
Parras, Juan (Universidad Politécnica de Madrid)
Ortega-Sabater, Carmen (University of Castilla-La Mancha)
Chulián, Salvador (Universidad de Cádiz)
Rosa, María (Universidad de Cádiz)
Cirillo, Davide (Barcelona Supercomputing Center)
García, Elena (Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús)
García, Jorge (Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús)
Manzano-Muñoz, Albert (Universitat de Barcelona)
Minguela, Alfredo (Instituto Murciano de Investigación Biosanitaria)
Fuster, Jose L. (Instituto Murciano de Investigación Biosanitaria)

Date:	2023
Abstract:	Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. Therefore, several research and innovation studies are focusing on pediatric relapsed or refractory ALL (R/R ALL). Driven by this context and following the European strategic plan to implement precision medicine equitably, the Relapsed ALL Network (ReALLNet) was launched under the umbrella of SEHOP in 2021, aiming to connect bedside patient care with expert groups in R/R ALL in an interdisciplinary and multicentric network. To achieve this objective, a board consisting of experts in diagnosis, management, preclinical research, and clinical trials has been established. The requirements of treatment centers have been evaluated, and the available oncogenomic and functional study resources have been assessed and organized. A shipping platform has been developed to process samples requiring study derivation, and an integrated diagnostic committee has been established to report results. These biological data, as well as patient outcomes, are collected in a national registry. Additionally, samples from all patients are stored in a biobank. This comprehensive repository of data and samples is expected to foster an environment where preclinical researchers and data scientists can seek to meet the complex needs of this challenging population. This proof of concept aims to demonstrate that a network-based organization, such as that embodied by ReALLNet, provides the ideal niche for the equitable and efficient implementation of "what's next" in the management of children with R/R ALL.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Relapsed acute lymphoblastic leukemia ; Precision medicine ; Cancer registry ; Artificial intelligence ; Functional assay
Published in:	Frontiers in Pediatrics, Vol. 11 (september 2023) , ISSN 2296-2360

DOI: 10.3389/fped.2023.1269560
PMID: 37800011

9 p, 686.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
Articles > Research articles
Articles > Published articles