Characterization and Factors Associated with Poor Asthma Control in Adults with Severe Eosinophilic Asthma
Padró-Casas, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Basagaña, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rivera-Ortún, María Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García-Olivé, Ignasi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pollan-Guisasola, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Teniente-Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez-Cáceres, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Navarro, José Tomás (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rosell, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Roger, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez-Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2023
Resum:	A study was conducted in 98 adult patients diagnosed with severe eosinophilic asthma (73. 5% women, mean age 47. 2 years) and followed prospectively for 1 year. The aim of the study was to characterize this population and to identify factors associated with poor prognosis at 1 year of follow-up. At the initial visit, uncontrolled severe asthma was diagnosed in 87. 7% of patients. Allergic sensitization was observed in 81. 7% (polysensitization in 17. 3%), with clinically significant allergic asthma in 45%. The mean percentage of sputum eosinophils was 4. 7% (standard deviation(SD) 6. 3%) and the mean (SD) blood eosinophil count 467 (225) cells/µL. Almost half of the patients (48. 3%) had sputum eosinophilia (>3% eosinophils). Sputum eosinophils correlated significantly with peripheral eosinophilia (p = 0. 004) and, to a lesser extent, with fractional exhaled nitric oxide (FeNO) (p = 0. 04). After 1 year, 48 patients (49%) had uncontrolled asthma in all visits, and 50 (51%) had controlled asthma in some visits. Airway obstruction (FEV < 80% predicted) was the main reason for uncontrolled asthma. In the multivariate analysis, an obstructive pattern (odds ratio (OR) 7. 45, 95% confidence interval (CI) 2. 41-23. 03, p < 0. 0001) and the patient's age (OR 1. 045, 95% CI 1. 005-1. 086, p = 0. 026) were independent predictors of poor asthma control. In adult-onset and long-standing asthma, serum interleukin (IL) IL-17 was higher in the uncontrolled asthma group. This study contributes to characterizing patients with severe eosinophilic asthma in real-world clinical practice.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Eosinophilic asthma ; Biomarkers ; Blood eosinophils ; Fractional exhaled nitric oxide ; Asthma control ; Periostin
Publicat a:	Journal of personalized medicine, Vol. 13 Núm. 7 (july 2023) , ISSN 2075-4426

DOI: 10.3390/jpm13071173
PMID: 37511786

16 p, 1.1 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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