Genetic and epigenetic defects of the RNA modification machinery in cancer
Orsolic, Ines (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Carrier, Arnaud (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Date: |
2023 |
Abstract: |
Cancer was initially considered to be an exclusively genetic disease, but an interplay of dysregulated genetic and epigenetic mechanisms is now known to contribute to the cancer phenotype. More recently, chemical modifications of RNA molecules - the so-called epitranscriptome - have been found to regulate various aspects of RNA function and homeostasis. Specific enzymes, known as RNA-modifying proteins (RMPs), are responsible for depositing, removing, and reading chemical modifications in RNA. Intensive investigations in the epitranscriptomic field in recent years, in conjunction with great technological advances, have revealed the critical role of RNA modifications in regulating numerous cellular pathways. Furthermore, growing evidence has revealed that RNA modification machinery is often altered in human cancers, highlighting the enormous potential of RMPs as pharmacological targets or diagnostic markers. |
Grants: |
Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1080 Agencia Estatal de Investigación RTI2018-094049-B-I00
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Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: |
Anglès |
Document: |
Ressenya ; recerca ; Versió publicada |
Published in: |
Trends in Genetics, Vol. 39 Núm. 1 (january 2023) , p. 74-88, ISSN 1362-4555 |
DOI: 10.1016/j.tig.2022.10.004
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Record created 2024-03-07, last modified 2024-05-04