Hyponatremia in Children and Adults with Prader-Willi Syndrome : A Survey Involving Seven Countries
Coupaye, Muriel (European Reference Network on Rare Endocrine Conditions)
Pellikaan, Karlijn (University Medical Centre Rotterdam)
Goldstone, Anthony (Imperial College London)
Crinò, Antonino (Bambino Gesù Hospital)
Grugni, Graziano (Istituto Auxologico Italiano)
Markovic, Tania (University of Sydney)
Høybye, Charlotte (Karolinska University Hospital and Karolinska Institutet (Suecia))
Caixàs i Pedragós, Assumpta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Mosbah, Helena (European Reference Network on Rare Endocrine Conditions)
De Graaff, Laura C. G. (University Medical Centre Rotterdam)
Tauber, Maithé (Institut Toulousain des Maladies Infectieuses et Inflammatoires)
Poitou, Christine (Sorbonne University)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	In Prader-Willi syndrome (PWS), conditions that are associated with hyponatremia are common, such as excessive fluid intake (EFI), desmopressin use and syndrome of inappropriate antidiuretic hormone (SIADH) caused by psychotropic medication. However, the prevalence of hyponatremia in PWS has rarely been reported. Our aim was to describe the prevalence and severity of hyponatremia in PWS. In October 2020, we performed a retrospective study based on the medical records of a large cohort of children and adults with PWS from seven countries. Among 1326 patients (68% adults), 34 (2. 6%) had at least one episode of mild or moderate hyponatremia (125 ≤ Na < 135 mmol/L). The causes of non-severe hyponatremia were often multi-factorial, including psychotropic medication in 32%, EFI in 24% and hyperglycemia in 12%. No obvious cause was found in 29%. Seven (0. 5%) adults experienced severe hyponatremia (Na < 125 mmol/L). Among these, five recovered completely, but two died. The causes of severe hyponatremia were desmopressin treatment for nocturnal enuresis (n = 2), EFI (n = 2), adrenal insufficiency (n = 1), diuretic treatment (n = 1) and unknown (n = 1). In conclusion, severe hyponatremia was very rare but potentially fatal in PWS. Desmopressin treatment for nocturnal enuresis should be avoided. Enquiring about EFI and monitoring serum sodium should be included in the routine follow-ups of patients with PWS.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Desmopressin ; Excessive fluid intake ; Hyponatremia ; Prader-Willi syndrome ; Syndrome of inappropriate antidiuretic hormone
Publicat a:	Journal of clinical medicine, Vol. 10 (august 2021) , ISSN 2077-0383

DOI: 10.3390/jcm10163555
PMID: 34441851

8 p, 258.5 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
Articles > Articles de recerca
Articles > Articles publicats