Long-term efficacy of dupilumab in severe asthma by baseline oral corticosteroid dose
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Rabe, Klaus F. (Observational and Pragmatic Research Institute)
Price, David (Universitair Ziekenhuis Gent)
Brusselle, Guy (National Jewish Health)
Wechsler, Michael E. (Regeneron Pharmaceuticals Inc.)
Xia, Changming (Sanofi)
Pandit-Abid, Nami (Sanofi)
Gall, Rebecca (Regeneron Pharmaceuticals Inc.)
Rowe, Paul J. (Sanofi)
Deniz, Yamo (Regeneron Pharmaceuticals Inc.)
Jacob-Nara, Juby A. (Sanofi)
Radwan, Amr (Regeneron Pharmaceuticals Inc.)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Dupilumab has been shown to improve clinical outcomes long term while reducing oral corticosteroid (OCS) dose in patients with severe OCS-dependent asthma. This post hoc analysis assesses the impact of OCS dose at baseline (≤10 or >10 mg·day −1) on long-term outcomes of dupilumab treatment. Annualised severe asthma exacerbation rates, forced expiratory volume in 1 s (FEV), measures of asthma control and quality of life, and OCS dose were evaluated in patients from the phase 3 VENTURE trial with severe OCS-dependent asthma, further categorised by OCS dose ≤10 or >10 mg·day −1 at parent study baseline (PSBL), who enrolled in TRAVERSE. Dupilumab reduced the annualised exacerbation rate in VENTURE, and it remained low throughout TRAVERSE (0. 202-0. 265 (OCS ≤10 mg·day −1 at PSBL) and 0. 221-0. 366 (OCS >10 mg·day −1 at PSBL)). Improvements in pre-bronchodilator FEV, asthma control and quality of life observed in VENTURE dupilumab patients were sustained throughout TRAVERSE. Patients on placebo during VENTURE showed rapid improvements in FEV upon initiating dupilumab in TRAVERSE, which were sustained to the end of TRAVERSE. Reductions in OCS dose observed in VENTURE were maintained throughout TRAVERSE, with more than two-thirds of patients achieving reductions in OCS doses to ≤5 mg·day −1 by TRAVERSE week 48. Improvements in clinical outcomes and reductions in OCS dose with dupilumab observed in VENTURE were maintained throughout TRAVERSE, regardless of baseline disease severity. Patients who switched from placebo in VENTURE to dupilumab in TRAVERSE had improved clinical outcomes and reductions in OCS dose comparable to those given dupilumab in VENTURE. Long-term treatment with dupilumab reduces asthma exacerbations, improves lung function, symptom control and quality of life, and reduces oral corticosteroid (OCS) use in patients with OCS-dependent asthma regardless of baseline OCS dose.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	ERJ Open Research, Vol. 9 (november 2023) , ISSN 2312-0541

DOI: 10.1183/23120541.00056-2023
PMID: 38020559

13 p, 1.1 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
Articles > Articles de recerca
Articles > Articles publicats