Burden of refractory and unexplained chronic cough on patients' lives : a cohort study
Puente, Luis (=))
Dávila, Ignacio (Hospital Clínico Universitario (Salamanca))
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid))
Crespo Lessmann, Astrid (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València))
Sola, Javier (Hospital Universitario Ramón y Cajal (Madrid))
Nieto, María Luisa (Hospital Arnau de Vilanova (València))
González-Barcala, Francisco-Javier (Universidade de Santiago de Compostela)
Cea-Calvo, Luis (Medical Affairs)
Sánchez-Jareño, Marta (Medical Affairs)
Rivas-Pardinas, Cristina (Medical Affairs)
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Chronic cough (cough lasting for ≥8 weeks) can lead to significant impairment in quality of life (QoL). Using patient-reported outcomes, this cohort study assessed the perceived impact of chronic cough on QoL and everyday life in patients from outpatient hospital clinics with refractory chronic cough (RCC) or unexplained chronic cough (UCC). This was a multicentre, non-interventional survey study. Cough severity was assessed on a 0−100 mm Visual Analogue Scale (VAS). Frequency, intensity and disruptiveness of cough were assessed using an adaptation of the Cough Severity Diary. The impact of cough on QoL was assessed using the Leicester Cough Questionnaire (LCQ). The physical impact of cough and associated impact on everyday life activities were explored using purpose-designed questions. 191 patients responded to the survey; 121 (63. 4%) had RCC and 149 were women (78. 0%). Mean score on the cough severity VAS was 62. 9 mm. Mean LCQ total score of 11. 9 indicated reduced QoL. Cough impaired patients' everyday life, including the inability to speak fluently (58. 0% of patients) and feeling tired/drained (46. 6%). Women perceived poorer chronic cough-related QoL than men, as reflected by lower LCQ scores, and greater impairment of physical health, including cough-related stress urinary incontinence, and psychological health. Patients with RCC/UCC experience a significant burden in their everyday life, including impaired QoL, and perceive a negative impact on physical and psychological health and everyday activities, affecting work, relationships and leisure activities. The impact appears to be greater in women than men for several of the aspects studied. Refractory and unexplained chronic cough significantly impair patients' quality of life, impacting their physical and psychological health, and everyday life. The impact appears to be stronger in women than men.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	ERJ Open Research, Vol. 9 (september 2023) , ISSN 2312-0541

DOI: 10.1183/23120541.00425-2023
PMID: 37753282

9 p, 526.0 KB

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