Amperometric Inkjet-Printed Thyroxine Sensor Based on Customized Graphene and Tunned Cyclodextrins as the Preconcentration Element
Ortiz-Aguayo, María Jesús (Universitat Autònoma de Barcelona. Departament de Química)
Paré, Franc (Universitat Autònoma de Barcelona. Departament de Química)
Gabriel, Gemma (Institut de Microelectrònica de Barcelona)
Baeza Labat, Maria del Mar (Universitat Autònoma de Barcelona. Departament de Química)

Data:	2024
Resum:	The determination of thyroid hormones has practical clinical significance for the diagnosis of hyperthyroidism and hypothyroidism diseases. Considering this aspect, a wide range of analytical methods for the detection of analytes, including immunoassay, chemiluminescence, mass spectroscopy and high-performance liquid chromatography, among others, has been developed. This type of analysis provides feasible results. Nevertheless, it requires qualified staff, special facilities and is time-consuming. For this reason, this paper relies on the fabrication of an electrochemical device developed with inkjet printing technology for the free detection of Thyroxine (T4). To manufacture our electrochemical device, several aspects were considered from the use of materials that amplify electrical signals, to finding a supramolecular scaffold that possess affinity towards the target analyte and the need of preconcentrating the analyte on the electrode's surface. For this task, printed devices were modified with a hybrid nanomaterial consisting of reduced graphene oxide (rGO) tuned with Au nanoparticles (Au-NPs) and an entrapment agent and different thiolated cyclodextrins (x-CD-SH) as carrying agents. Analytes were preconcentrated via supramolecular chemistry due to the formation of an inclusion complex between the cyclodextrin and hormones. Morphological and electrochemical characterization of the final device was carried out to ensure the proper workability of the electrode, achieving excellent response, sensitivity and limit of detection (LOD).
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2019/LLAV-00027
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Thyroid hormones ; Electrochemical (bio)sensor ; Graphene ; Β (beta)-cyclodextrin ; Γ (gamma)-cyclodextrin
Publicat a:	Nanomaterials, Vol. 14, Num. 5 (February 2024) , art. 403, ISSN 2079-4991

DOI: 10.3390/nano14050403
PMID: 38470734

11 p, 1.9 MB

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