The gut microbiome of Baka forager-horticulturalists from Cameroon is optimized for wild plant foods
Rampelli, Simone (University of Bologna)
Gallois, Sandrine (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals)
D'Amico, Federica (University of Bologna)
Turroni, Silvia (University of Bologna)
Fabbrini, Marco (University of Bologna)
Scicchitano, Daniel (University of Bologna)
Candela, Marco (University of Bologna)
Henry, Amanda (Leiden University)

Date:	2024
Abstract:	The human gut microbiome is losing biodiversity, due to the "microbiome modernization process" that occurs with urbanization. To keep track of it, here we applied shotgun metagenomics to the gut microbiome of the Baka, a group of forager-horticulturalists from Cameroon, who combine hunting and gathering with growing a few crops and working for neighboring Bantu-speaking farmers. We analyzed the gut microbiome of individuals with different access to and use of wild plant and processed foods, to explore the variation of their gut microbiome along the cline from hunter-gatherer to agricultural subsistence patterns. We found that 26 species-level genome bins from our cohort were pivotal for the degradation of the wild plant food substrates. These microbes include Old Friend species and are encoded for genes that are no longer present in industrialized gut microbiome. Our results highlight the potential relevance of these genes to human biology and health, in relation to lifestyle.
Grants:	European Commission 818290 European Commission 677576
Note:	Unidad de excelencia María de Maeztu CEX2019-000940-M
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Diet ; Microbiome
Published in:	iScience, Vol. 27, Issue 3 (March 2024) , art. 109211, ISSN 2589-0042

DOI: 10.1016/j.isci.2024.109211
PMID: 38433907

22 p, 4.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Institut de Ciència i Tecnologia Ambientals (ICTA)
Articles > Research articles
Articles > Published articles