Cefepime Dosing Requirements in Elderly Patients Attended in the Emergency Rooms
Ruiz Ramos, Jesus (Institut d'Investigació Biomèdica Sant Pau)
Herrera, Sergio (Institut d'Investigació Biomèdica Sant Pau)
López-Vinardell, Laia (Institut d'Investigació Biomèdica Sant Pau)
Juanes-Borrego, Ana (Institut d'Investigació Biomèdica Sant Pau)
Puig Campmany, Mireia (Institut d'Investigació Biomèdica Sant Pau)
Mangues, Ma Antonia (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	This study aimed to assess the probability of reaching an adequate pharmacokinetic/pharmacodynamic (pK/pD) index for different cefepime dosages in frail patients with bacteremia treated in the emergency room. Simulation study based on Gram-negative bacterial strains that cause bacteremia. The probability of reaching a time above the minimum inhibitory concentration (MIC) at 50% and 100% dosing intervals (fT > 50 and fT > 80% MIC) was assessed for two different renal clearance intervals. One hundred twenty nine strains were collected, the predominant species being Escherichia coli (n = 83 [64. 3%]). In patients with a ClCr of 30 mL/min, an fT > 50% MIC was reached in more than 90% of the simulations. However, a dose of at least 1 g every 12 h must be administered to reach an fT > 80% MIC. In patients with a ClCr of 30-60 mL/min, the probability of reaching an fT > 50% MIC was higher than 90% with doses of 1 g every 8 h or more, but this value was not reached in > 90% simulations for any of the doses tested in this study. Standard cefepime dosing can reach an adequate PK/PD index in frail patients. Nevertheless, a high dose or extended infusion is necessary to reach an fT > 80% MIC in patients with a ClCr > 60 mL/min.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Anging ; Dose response ; Infection ; Pharmacokinetics
Published in:	Dose-Response, Vol. 20 Núm. 1 (31 2022) , ISSN 1559-3258

DOI: 10.1177/15593258221078393
PMID: 35237115

5 p, 705.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles