Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study
Sánchez, Enric (Universitat de Lleida)
Kerkeni, Mohsen (University of Monastir (Tunísia))
Hernández, Marta (Universitat de Lleida)
Gavaldà, Ricard (Universitat Politècnica De Catalunya)
Rius Riu, Ferran (Institut de Recerca Biomèdica de Lleida)
Sauret, Ariadna (Universitat de Lleida)
Torres, Gerard (Institut de Recerca Biomèdica de Lleida)
Bermúdez-López, Marcelino (Institut de Recerca Biomèdica de Lleida)
Fernández, Elvira (Institut de Recerca Biomèdica de Lleida)
Castro-Boqué, Eva (Institut de Recerca Biomèdica de Lleida)
Purroy, Francisco (Institut de Recerca Biomèdica de Lleida)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Farràs-Sallés, Cristina (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Buti, Miquel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Godoy, Pere (Institut de Recerca Biomèdica de Lleida)
Pamplona, Reinald (Universitat de Lleida)
Lecube, Albert (Institut de Recerca Biomèdica de Lleida)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5. 7 to 6. 4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50. 1% women with an age of 57 [52;62] years, a BMI of 28. 3 [25. 4;31. 6] kg/m, and a prevalence of prediabetes of 34. 5%. Participants with prediabetes showed higher SAF than control participants (2. 0 [1. 7;2. 2] vs. 1. 9 [1. 7;2. 2], p < 0. 001). However, HbA1c was not significantly correlated with SAF levels (r = 0. 026, p = 0. 090). In addition, the SAF level was not independently associated with prediabetes (OR = 1. 12 (0. 96 to 1. 30)). Finally, there was no good cutoff point for SAF to identify patients with prediabetes (AUC = 0. 52 (0. 50 to 0. 54), sensitivity = 0. 61, and 1-specificity = 0. 56). Given all of this evidence, we can conclude that although there is an increase in SAF levels in participants with prediabetes, the applicability and clinical relevance of the results is low in this population.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Advanced glycation end-products ; Glycosylated hemoglobin ; Prediabetes ; Skin autofluorescence
Published in:	Nutrients, Vol. 14 Núm. 5 (3-1 2022) , p. 1102, ISSN 2072-6643

DOI: 10.3390/nu14051102
PMID: 35268075

8 p, 1.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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