Complications of Autologous Stem Cell Transplantation in Multiple Myeloma : Results from the CALM Study
Waszczuk-Gajda, A. (University Clinical Centre-The Medical University of Warsaw)
Penack, O. (Charité - Universitätsmedizin Berlin)
Sbianchi, G. (Tor Vergata University)
Koster, L. (EBMT Data Office Leiden)
Blaise, D. (Institut Paoli Calmettes)
Reményi, P. (Dél-Pesti Centrumkórház)
Russell, N. (Nottingham University)
Ljungman, P. (Karolinska Institutet (Estocolm, Suècia))
Trneny, M. (University Hospital)
Mayer, J. (University Hospital Brno (República Txeca))
Iacobelli, S. (Tor Vergata University)
Kobbe, G. (Heinrich Heine Universitaet)
Scheid, C. (University of Cologne)
Apperley, Jane (Imperial College)
Touzeau, C. (CHU Nantes)
Lenhoff, S. (Skanes University Hospital)
Jantunen, E. (Kuopio University Hospital)
Anagnostopoulos, Achilles (George Papanicolaou General Hospital (Tessalònica, Grècia))
Paris, L. (SST Papa Giovanni XXIII)
Browne, P. (Hope Directorate)
Thieblemont, C. (Hôpital St. Louis)
Schaap, N. (Radboud University Medical Centre)
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau)
Yakoub-Agha, I. (CHU de Lille)
Garderet, L. (Hôpital Pitié Salpetrière)
Styczynski, J. (Collegium Medicum UMK)
Schoemans, H. (KU Leuven-University of Leuven)
Moiseev, I. (Pavlov University)
Duarte, R. F. (Hospital Universitario Puerta de Hierro Majadahonda)
Peric, Z. (University of Zagreb)
Montoto, Silvia (St Bartholomew's Hospital)
van Biezen, A. (EBMT Data Office Leiden)
Mikulska, M. (IRC CS Ospedale Policlinico San Martino)
Aljurf, Mahmoud (King Faisal Specialist Hospital Center and Research)
Ruutu, T. (Helsinki University Hospital)
Kröger, N. (University Hospital Eppendorf)
Morris, C. (Belfast City Hospital)
Koenecke, C. (Hannover Medical School)
Schoenland, S. (Heidelberg University Hospital (Alemanya))
Basak, G.W. (University Clinical Centre-The Medical University of Warsaw)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short-and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). Methods: The analysis included all patients with MM from the CALM study who underwent ≥1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0-100 days, 101 days-1 year, and >1 year after the first transplant. Results: The analysis included a total of 3552 patients followed up for a median of 56. 7 months (range 0. 4-108. 1). Complication rates decreased with the time from ASCT with 24. 85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2. 31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45. 7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6. 5 cases per 100 patient-years, 95% CI: 6. 1-7. 0) and gastrointestinal complications (4. 7 cases per 100 patient-years, 95% CI: 4. 3-5. 1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. Conclusions: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Autologous stem cell transplantation in multiple myeloma ; Complications ; Multiple myeloma
Publicat a:	Journal of clinical medicine, Vol. 11 Núm. 12 (6-2 2022) , p. 3541, ISSN 2077-0383

DOI: 10.3390/jcm11123541
PMID: 35743620

10 p, 1.0 MB

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