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| Pàgina inicial > Articles > Articles publicats > Adipokines as New Biomarkers of Immune Recovery : |
(Instituto de Salud Carlos III) (Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions)| Data: | 2022 |
| Resum: | A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4 T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4 T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4 T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0. 043 and p = 0. 034), and they remained lower during all ART follow-up visits (p = 0. 044 and p = 0. 028 for APLNR, p = 0. 038 and p = 0. 010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0. 01), and low circulating RBP4 concentrations were related to a low CD4 T-cell gain (p = 0. 018 and p = 0. 039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4 T cells at 144 weeks (p < 0. 001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response. |
| Ajuts: | Ministerio de Economía y Competitividad PI16/00503 Ministerio de Economía y Competitividad RD12/0017/0005 Ministerio de Economía y Competitividad RD16/0025/0006 Instituto de Salud Carlos III PI18/01216 Instituto de Salud Carlos III PI19/01337 Instituto de Salud Carlos III PI20/00326 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Adipokines ; Antiretroviral therapy ; HIV ; Immunodiscordant response ; Poor immune recovery |
| Publicat a: | International journal of molecular sciences, Vol. 23 Núm. 4 (2-2 2022) , p. 2202, ISSN 1422-0067 |
