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Pàgina inicial > Articles > Articles publicats > Increased brain fractional perfusion in obesity using intravoxel incoherent motion (IVIM) MRI metrics |
Data: | 2024 |
Descripció: | 12 pàg. |
Resum: | Objective: This research seeks to shed light on the associations between brain perfusion, cognitive function, and mental health in individuals with and without obesity. Methods: In this study, we employed the noninvasive intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) technique to examine brain fractional perfusion (FP) in two groups: individuals with obesity (N = 72) and healthy controls (N = 66). Additionally, we investigated potential associations between FP, cognitive function, and depressive symptoms in the participants with and without obesity. Finally, artificial intelligence algorithms (Boruta analysis) were also used. Results: Participants with obesity exhibited increased FP within dopaminergic brain circuits, particularly involving prefrontal cortex areas, anterior and posterior sections of the cingulate cortex, the right striatum, and the midbrain. Additionally, these individuals demonstrated lower working memory and higher depressive symptoms compared to the control group. Notably, higher FP in the inferior temporal and occipital cortices correlated with greater depressive symptoms, whereas increased FP in the right ventral caudate and the midbrain was associated with better working memory performance. A link between inflammatory and metabolic variables, with a particular emphasis on monocytes, and FP in obesity was also evidenced by Boruta analysis. Conclusions: Increased brain perfusion in individuals with obesity is associated with cognitive function and mental health through interaction with metabolic and inflammatory factors. |
Ajuts: | Ministerio de Economía y Competitividad RD16/0017/0020 Ministerio de Economía y Competitividad PI15/01934 Instituto de Salud Carlos III PI18/01022 Instituto de Salud Carlos III PI21/01361 |
Nota: | Altres ajuts: acords transformatius de la UAB |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Publicat a: | Obesity, Vol. 32 Núm. 4 (april 2024) , p. 756-767, ISSN 1930-7381 |
12 p, 3.5 MB |