The Role of Digital Rectal Examination Prostate Volume Category in the Early Detection of Prostate Cancer : Its Correlation with the Magnetic Resonance Imaging Prostate Volume
Morote Robles, Juan (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Picola, Natàlia (Hospital Universitari de Bellvitge)
Muñoz-Rodríguez, Jesús (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Paesano, Nahuel (Clinica Creu Blanca)
Ruiz-Plazas, Xavier (Hospital Universitari Joan XXIII de Tarragona)
Muñoz-Rivero, Marta V. (Hospital Universitari Arnau de Vilanova)
Celma, Ana (Universitat Autònoma de Barcelona. Departament de Cirurgia)
García-de Manuel, Gemma (Hospital Universitari de Girona Doctor Josep Trueta)
Miró, Berta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Abascal, Jose Maria (Parc de Salut MAR de Barcelona)
Servian, Pol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Date:	2024
Abstract:	To relate the prostate volume category (PVC) assessed with digital rectal examination (DRE)-small, median, and large-and the prostate volumes (PVs) assessed with magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS). To compare the clinically significant prostate cancer (csPCa) discrimination ability of two predictive models based on DRE-PVC and MRI-PV. A prospective trial of 2,090 men with prostate-specific antigen >3 ng/mL and/or PCa suspicious DRE were prospectively recruited in 10 centers from Catalonia (Spain), between 2021 and 2022, in whom DRE-PVC was assessed. Pre-biopsy MRI, and 12-core TRUS-random biopsy was always performed after 2- to 6-core TRUS-fusion targeted biopsy of prostate imaging-report and data system >3 lesions. In 370 men (17. 7%) the DRE-PVC was unconclusive. Among the 1,720 men finally analyzed the csPCa (grade group >2) detection was 42. 4%. The median (interquartile range) of TRUS and MRI-PVs of small prostates were 33 mL (19-37 mL) and 35 mL (23-30 mL), p=0. 410; in median prostates they were 51 mL (38-58 mL) and 55 mL (48-63 mL) respectively, p<0. 001; in large prostates 80 mL (60-100 mL) and 95 mL (75-118 mL) respectively, p<0. 001. The predictive models sharing the MRI-PV and DRE-PVC showed areas under the curves of 0. 832 (95% confidence interval [CI], 0. 813-0. 851) and 0. 828 (95% CI, 0. 809-0. 848) respectively, p=0. 632, as well as similar net benefit and clinical utility. PVC was unconclusive in 17% of DREs. MRI-PV overestimated the TRUS-PV in median and large prostates. The predictive models based on MRI-PV and DRE-PVC showed similar efficacy to predict csPCa. PVC assessed with DRE is helpful to predict the csPCa risk before MRI.
Grants:	Instituto de Salud Carlos III PI20/01666
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Digital rectal examination ; Magnetic resonance imaging ; Predictive model ; Prostate volume ; Prostate volume category ; Transrectal ultrasound
Published in:	The world journal of men's health, Vol. 42 (january 2024) , p. 441-448, ISSN 2287-4690

DOI: 10.5534/wjmh.230028
PMID: 38164025

8 p, 1.3 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles