Gut microbial dysbiosis in patients with Cushing's disease in long-term remission. Relationship with cardiometabolic risk
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Manichanh, Chaysavanh (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Amodru, Vincent (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Fernández, Pedro González (Hospital Universitario de Cruces (Barakaldo, País Basc))
Gaztambide, Sonia (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Yañez, Francisca (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Martel-Duguech, Luciana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Webb, Susan M. (Universitat Autònoma de Barcelona. Departament de Medicina)

Fecha:	2023
Resumen:	Patients with Cushing's disease (CD) in remission maintain an increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis) have been associated with several cardiometabolic risk factors. Twenty-eight female non-diabetic patients with CD in remission with a mean ± SD) age of 51 ± 9 years, mean (± SD) BMI, 26 ± 4, median (IQR) duration of remission, 11(4) years and 24 gender-, age, BMI-matched controls were included. The V4 region of the bacterial 16S rDNA was PCR amplified and sequenced to analyse microbial alpha diversity (Chao 1 index, observed number of species, Shannon index) and beta diversity analysis through the Principal Coordinates Analysis (PCoA) of weighted and unweighted UniFrac distances. Inter-group difference in microbiome composition was analysed using MaAsLin2. The Chao 1 index was lower in CD as compared with controls (Kruskal-Wallis test, q = 0. 002), indicating lower microbial richness in the former. Beta diversity analysis showed that faecal samples from CS patients clustered together and separated from the controls (Adonis test, p<0. 05). Collinsella, a genus form of the Actinobacteria phylum was present in CD patients only, whereas Sutterella, a genus from Proteobacteria phylum, was scarcely detectable/undetectable in CD patients as well as Lachnospira, a genus of the Lachnospiraceae family of the Firmicutes phylum. In CS, the Chao 1 index was associated with fibrinogen levels and inversely correlated with both triglyceride concentrations and the HOMA-IR index (p<0. 05). Patients with CS in remission have gut microbial dysbiosis which may be one of the mechanisms whereby cardiometabolic dysfunctions persist after "cure".
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Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cushing's disease ; Microbiota ; Cardiovascular risk ; Triglycerides ; Fibrinogen
Publicado en:	Frontiers in endocrinology, Vol. 14 (june 2023) , ISSN 1664-2392

DOI: 10.3389/fendo.2023.1074757
PMID: 37342265

10 p, 1.6 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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