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5 p, 615.7 KB |
Acute elbow dislocation : a critical appraisal of the literature
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Barco, Raul (Hospital Universitario La Paz (Madrid)) ;
Gonzalez-Escobar, Sergio (Hospital Vithas San José) ;
Acerboni-Flores, Francesc (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vaquero-Picado, Alfonso (Hospital Universitario La Paz (Madrid)) ;
Universitat Autònoma de Barcelona
The purpose of this study was to perform a narrative review of acute elbow dislocation (AED). There are certain aspects of the management of AED that are controversial, including type and length of immobilization, indications for surgery, type of surgery, and new evidence available. [...]
2023 -  10.1016/j.jseint.2023.03.019
JSES International, Vol. 7 (april 2023) , p. 2560-2564
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29 p, 5.2 MB |
Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
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Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortega-Sabater, C. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Thampi, Namitha (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández Fuentes, Narcís (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guerrero Murillo, Mercedes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez Moreno, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vinyoles, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Campos, Diana (DiNA Science. S.A) ;
Giménez, Carles (DiNA Science. S.A) ;
Boer, Judith M. (Princess Maxima Center for Pediatric Oncology) ;
den Boer, Monique L. (Department of Pediatric Oncology and Hematology. Erasmus Medical Center - Sophia Children's Hospital) ;
Calvo, Gabriel F. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Camós, Mireia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Fuster, José Luis (Instituto Murciano de Investigación Biosanitaria) ;
Velasco, P. (Hospital Universitari Vall d'Hebron) ;
Ballerini, Paola (AP-HP. Service of Pediatric Hematology. Hopital Armand Trousseau) ;
Locatelli, Franco (Bambino Gesù Children's Hospital) ;
Mullighan, Charles G. (Department of Pathology. St. Jude Children's Research Hospital) ;
Spierings, Diana C.J. (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Foijer, Floris (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Pérez-García, Víctor M. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Chromosomal instability (CIN) lies at the core of cancer development leading to aneuploidy, chromosomal copy-number heterogeneity (chr-CNH) and ultimately, unfavorable clinical outcomes. Despite its ubiquity in cancer, the presence of CIN in childhood B-cell acute lymphoblastic leukemia (cB-ALL), the most frequent pediatric cancer showing high frequencies of aneuploidy, remains unknown. [...]
2024 - 10.1038/s44321-023-00006-w
EMBO Molecular Medicine, Vol. 16 Núm. 1 (16 2024) , p. 64-92
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Determination of the time constant distribution of a defect-centric time-dependent variability model for Sub-100-nm FETs
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Saraza-Canflanca, Pablo (Instituto de Microelectrónica de Sevilla) ;
Castro-Lopez, Rafael (Instituto de Microelectrónica de Sevilla) ;
Roca, Elisenda (Instituto de Microelectrónica de Sevilla) ;
Martin Martinez, Javier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Rodríguez Martínez, Rosana (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Nafría i Maqueda, Montserrat (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Fernandez, Francisco V. (Instituto de Microelectrónica de Sevilla)
The origin of some time-dependent variability phenomena in FET technologies has been attributed to the charge carrier trapping/detrapping activity of individual defects present in devices. Although some models have been presented to describe these phenomena from the so-called defect-centric perspective, limited attention has been paid to the complex process that goes from the experimental data of the phenomena up to the final construction of the model and all its components, specifically the one that pertains to the time constant distribution. [...]
2022 - 10.1109/TED.2022.3198383
IEEE Transactions on Electron Devices, Vol. 69, issue 10 (Oct. 2022) , p. 5424-5429
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Random Telegraph Noise and Bias Temperature Instabilities statistical characterization of Ω-gate FDSOI devices at low voltages
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Pedreira Rincon, Gerard (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Martin Martinez, Javier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Crespo Yepes, Albert (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Amat Bertran, Esteve (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Rodríguez Martínez, Rosana (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Nafría i Maqueda, Montserrat (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica)
Random Telegraph Noise (RTN) and Bias Temperature Instabilities (BTI) are two mechanisms that can significantly reduce the performance and reliability of integrated circuits. In scaled devices, both phenomena are stochastic, so that a statistical analysis is required to accurately evaluate their impact on a particular technology. [...]
2023 - 10.1016/j.sse.2023.108735
Solid-state electronics, Vol. 209 (November 2023) , art. 108735
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11 p, 458.4 KB |
Pembrolizumab in Asian patients with microsatellite-instability-high/mismatch-repair-deficient colorectal cancer
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Yoshino, Takayuki (National Cancer Center Hospital East) ;
André, Thierry (Sorbonne University) ;
Kim, Tae Won (University of Ulsan) ;
Yong, Wei Peng (National University Cancer Institute) ;
Shiu, Kai-Keen (University College Hospital) ;
Jensen, Benny Vittrup (Herlev and Gentofte Hospital) ;
Jensen, Lars Henrik (University Hospital of Southern Denmark) ;
Punt, Cornelis J. A. (University Medical Center Utrecht) ;
Smith, Denis (Hôpital Haut-Lévêque) ;
García-Carbonero, Rocío (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Alcaide-Garcia, Julia (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Gibbs, Peter (Western Hospital) ;
de la Fouchardiere, Christelle (Centre Léon Bérard) ;
Rivera, Fernando (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Elez, Elena (Vall d'Hebron Institut d'Oncologia) ;
Le, Dung T. (Johns Hopkins Medicine) ;
Adachi, Noriaki (Merck (Estats Units d'Amèrica)) ;
Fogelman, David (Merck(Estats Units d'Amèrica)) ;
Marinello, Patricia (Merck (Estats Units d'Amèrica)) ;
Diaz, Luis A. (Memorial Sloan Kettering Cancer Center) ;
Universitat Autònoma de Barcelona
The phase 3 KEYNOTE-177 study evaluated pembrolizumab versus chemotherapy with or without bevacizumab or cetuximab in patients with newly diagnosed, microsatellite-instability-high (MSI-H)/mismatch-repair-deficient (dMMR) metastatic colorectal cancer (mCRC). [...]
2022 - 10.1111/cas.15650
Cancer Science, Vol. 114 (december 2022) , p. 1026-1036
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22 p, 2.7 MB |
Somatic hypomethylation of pericentromeric sst1 repeats and tetraploidization in human colorectal cancer cells
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González Fernández, Beatriz (Institut Germans Trias i Pujol) ;
Navarro Jiménez, Maria (Institut Germans Trias i Pujol) ;
Alonso De Gennaro, María José (Institut Germans Trias i Pujol) ;
Jansen, Sanne Marcia (Institut Germans Trias i Pujol) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Perucho, Manuel (Sanford Burnham Prebys Medical Discovery Institute (SBP)) ;
Alonso, Sergio (Institut Germans Trias i Pujol)
Somatic DNA hypomethylation and aneuploidy are hallmarks of cancer, and there is evidence for a causal relationship between them in knockout mice but not in human cancer. The non-mobile pericentromeric repetitive elements SST1 are hypomethylated in about 17% of human colorectal cancers (CRC) with some 5-7% exhibiting strong age-independent demethylation. [...]
2021 - 10.3390/cancers13215353
Cancers, Vol. 13 Núm. 21 (11-1 2021) , p. 5353
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14 p, 2.4 MB |
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
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Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ;
Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia)) ;
Rajagopal, Varshni (Karolinska Institutet (Estocolm, Suècia)) ;
Zhenjun, Zhao (Karolinska Institutet (Estocolm, Suècia)) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Müller, Sarah (Karolinska Institutet (Estocolm, Suècia)) ;
Hanna, Bishoy M. F. (Karolinska Institutet (Estocolm, Suècia)) ;
Loseva, Olga (Karolinska Institutet (Estocolm, Suècia)) ;
Wallner, Olov (Karolinska Institutet (Estocolm, Suècia)) ;
Michel, Maurice (Karolinska Institutet (Estocolm, Suècia)) ;
Rodriguez-Perales, Sandra (Grupo de Citogenética Molecular. Programa de Genética del Cáncer Humano. Centro Nacional de Investigaciones Oncológicas de España (Madrid)) ;
Gad, Helge (The University of Sheffield) ;
Visnes, Torkild (SINTEF Industry (Noruega)) ;
Helleday, Thomas (The University of Sheffield) ;
Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Universitat Autònoma de Barcelona
The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome instability. [...]
2021 - 10.1038/s41598-021-82917-7
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 3490
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16 p, 1.6 MB |
Phase 2 Trial (POLA Study) of Lurbinectedin plus Olaparib in Patients with Advanced Solid Tumors : Results of Efficacy, Tolerability, and the Translational Study
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Poveda, Andres (Hospital Quironsalud (Valencia). Oncogynecologic Department) ;
Lopez-Reig, Raquel (Fundació Institut Valencià d'Oncologia) ;
Oaknin, Ana (Vall d'Hebron Institut d'Oncologia) ;
Redondo, Andres (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Rubio, Maria Jesus (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Guerra, Eva (Hospital Universitario Ramón y Cajal (Madrid)) ;
Fariñas-Madrid, Lorena (Vall d'Hebron Institut d'Oncologia) ;
Gallego, Alejandro (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Rodriguez-Freixinos, Victor (Vall d'Hebron Institut d'Oncologia) ;
Fernandez-Serra, Antonio (Fundació Institut Valencià d'Oncologia) ;
Juan, Óscar (Pivotal SLU (Madrid)) ;
Romero, Ignacio (Fundació Institut Valencià d'Oncologia) ;
López-Guerrero, J.A (Fundació Institut Valencià d'Oncologia)
Genomic instability (GI) is a transversal phenomenon in oncology, constituting a hallmark of cancer. In gynecological malignancies, the predictive value of GI has been described and is mainly caused by alterations in the homologous recombination repair (HRR) genes, such as BRCA1/2. [...]
2022 - 10.3390/cancers14040915
Cancers, Vol. 14 Núm. 4 (february 2022)
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8 p, 946.1 KB |
Preliminary Findings on CTG Expansion Determination in Different Tissues from Patients with Myotonic Dystrophy Type 1
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Ballester-Lopez, Alfonsina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Koehorst, Emma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Linares-Pardo, Ian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Núñez-Manchón, Judit (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Almendrote, Míriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lucente, Giuseppe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arbex, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puente-Alonso, Carles (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lucia, Alejandro (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Monckton, Darren G. (Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK) ;
Cumming, Sarah A. (Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK) ;
Pintos-Morell, Guillem (Hospital Universitari Vall d'Hebron) ;
Coll-Cantí, Jaume (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramos-Fransi, Alba (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Piñeiro, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nogales, Gisela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Myotonic Dystrophy type 1 (DM1) is characterized by a high genetic and clinical variability. Determination of the genetic variability in DM1 might help to determine whether there is an association between CTG (Cytosine-Thymine-Guanine) expansion and the clinical manifestations of this condition. [...]
2020 - 10.3390/genes11111321
Genes, Vol. 11 (november 2020)
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