Excellent Response to OnabotulinumtoxinA : Different Definitions, Different Predictors
Ornello, Raffaele (University of L'Aquila)
Baraldi, Carlo (AOU Policlinico di Modena)
Ahmed, Fayyaz (Hull University Teaching Hospitals)
Negro, Andrea (Sapienza University)
Miscio, Anna Maria (Fondazione IRCCS "Casa Sollievo Della Sofferenza")
Santoro, Antonio (Fondazione IRCCS "Casa Sollievo Della Sofferenza")
Alpuente, Alicia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Russo, Antonio (University of Campania "Luigi Vanvitelli")
Silvestro, Marcello (University of Campania "Luigi Vanvitelli")
Cevoli, Sabina (IRCCS Istituto delle Scienze Neurologiche di Bologna)
Brunelli, Nicoletta (Campus Bio-Medico University Hospital (Itàlia))
Vernieri, Fabrizio (Campus Bio-Medico University Hospital (Itàlia))
Grazzi, Licia (IRCCS Foundation "Carlo Besta" Neurological Institute)
Pani, Luca (VeraSci (Estats Units d'Amèrica))
Andreou, Anna P (Guy's and St Thomas' NHS Foundation Trust (Regne Unit))
Lambru, Giorgio (Guy's and St Thomas' NHS Foundation Trust (Regne Unit))
Frattale, Ilaria (Tor Vergata University)
Kamm, Katharina (Ludwig Maximilians University München)
Ruscheweyh, Ruth (Ludwig Maximilians University München)
Russo, Marco (Azienda USL-IRCCS di Reggio Emilia)
Torelli, Paola (University of Parma)
Filatova, Elena (Sechenov First Moscow State Medical University)
Latysheva, Nina (Sechenov First Moscow State Medical University)
Gryglas-Dworak, Anna (Headache Center Wroclaw)
Straburzyński, Marcin (University of Warmia and Mazury)
Butera, Calogera (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Colombo, Bruno (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Filippi, Massimo (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Pozo-Rosich, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Martelletti, Paolo (Sapienza University)
Guerzoni, Simona (University of Modena and Reggio Emilia)
Sacco, Simona (University of L'Aquila)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	The identification of patients who can benefit the most from the available preventive treatments is important in chronic migraine. We explored the rate of excellent responders to onabotulinumtoxinA in a multicenter European study and explored the predictors of such response, according to different definitions. A pooled analysis on chronic migraineurs treated with onabotulinumtoxinA and followed-up for, at least, 9 months was performed. Excellent responders were defined either as patients with a ≥75% decrease in monthly headache days (percent-based excellent responders) or as patients with <4 monthly headache days (frequency-based excellent responders). The characteristics of excellent responders at the baseline were compared with the ones of patients with a <30% decrease in monthly headache days. Percent-based excellent responders represented about 10% of the sample, whilst frequency-based excellent responders were about 5% of the sample. Compared with non-responders, percent-based excellent responders had a higher prevalence of medication overuse and a higher excellent response rate even after the 1st and the 2nd injection. Females were less like to be frequency-based excellent responders. Chronic migraine sufferers without medication overuse and of female sex may find fewer benefits with onabotulinumtoxinA. Additionally, the excellent response status is identifiable after the first cycle.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Chronic migraine ; Onabotulinumtoxina ; Predictors of response ; Excellent responders
Publicat a:	International journal of environmental research and public health, Vol. 19 (september 2022) , ISSN 1660-4601

DOI: 10.3390/ijerph191710975
PMID: 36078699

12 p, 503.9 KB

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