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1.
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9 p, 1.1 MB |
MELD 3.0 adequately predicts mortality and renal replacement therapy requirements in patients with alcohol-associated hepatitis
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Díaz, Luis Antonio (Pontificia Universidad Católica de Chile) ;
Fuentes-López, Eduardo (Pontificia Universidad Católica de Chile) ;
Ayares, Gustavo (Pontificia Universidad Católica de Chile) ;
Idalsoaga, Francisco (Pontificia Universidad Católica de Chile) ;
Arnold, Jorge (Pontificia Universidad Católica de Chile) ;
Valverde, María Ayala (Hospital El Pino) ;
Perez, Diego (Hospital El Pino) ;
Gómez, Jaime (Hospital El Pino) ;
Escarate, Rodrigo (Hospital El Pino) ;
Villalón, Alejandro (Universidad de Antofagasta) ;
Ramírez, Carolina A. (Western University) ;
Hernandez-Tejero, Maria (Hospital Clínic i Provincial de Barcelona) ;
Zhang, Wei (Massachusetts General Hospital) ;
Qian, Steve (University of Florida) ;
Simonetto, Douglas A. (Mayo Clinic) ;
Ahn, Joseph C. (Mayo Clinic) ;
Buryska, Seth (Mayo Clinic) ;
Dunn, Winston (University of Kansas Medical Center) ;
Mehta, Heer (University of Kansas Medical Center) ;
Agrawal, Rohit (University of Illinois) ;
Cabezas, Joaquín (Instituto de Investigación Valdecilla (IDIVAL)) ;
García-Carrera, Inés (Instituto de Investigación Valdecilla (IDIVAL)) ;
Cuyàs, Berta (Institut d'Investigació Biomèdica Sant Pau) ;
Poca Sans, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
Sarin, Shiv K. (Institute of Liver and Biliary Sciences) ;
Maiwall, Rakhi (Institute of Liver and Biliary Sciences) ;
Jalal, Prasun K. (Baylor College of Medicine) ;
Abdulsada, Saba (Baylor College of Medicine) ;
Higuera-de-la-Tijera, Fátima (Universidad Nacional Autónoma de México) ;
Kulkarni, Anand V. (Asian Institute of Gastroenterology) ;
Rao, P. Nagaraja (Asian Institute of Gastroenterology) ;
Salazar, Patricia Guerra (Instituto de Gastroenterología Boliviano-Japonés) ;
Skladaný, Lubomir (Slovak Medical University) ;
Bystrianska, Natália (Slovak Medical University) ;
Clemente-Sanchez, Ana (CIBERehd Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Madrid) ;
Villaseca-Gómez, Clara (CIBERehd Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Madrid) ;
Haider, Tehseen (Montefiore Medical Center) ;
Chacko, Kristina R. (Montefiore Medical Center) ;
Romero, Gustavo A. (Hospital de Gastroenterología Dr. Carlos Bonorino Udaondo) ;
Pollarsky, Florencia D. (Hospital de Gastroenterología Dr. Carlos Bonorino Udaondo) ;
Restrepo, Juan Carlos (Unidad de Hepatología del Hospital Pablo Tobon Uribe) ;
Castro-Sanchez, Susana (Grupo de Gastrohepatología de la Universidad de Antioquia) ;
Toro, Luis G. (Hospitales de San Vicente Fundación de Medellín y Rionegro) ;
Yaquich, Pamela (Hospital San Juan de Dios) ;
Mendizabal, Manuel (Hospital Universitario Austral) ;
Garrido, Maria Laura (Hospital Central Dr. Ramon Carrillo) ;
Marciano, Sebastián (Hospital Italiano de Buenos Aires) ;
Dirchwolf, Melisa (Hospital Privado de Rosario) ;
Vargas Blasco, Víctor (Hospital Universitari Vall d'Hebron) ;
Jiménez, Cesar (Hospital Universitari Vall d'Hebron) ;
Louvet, Alexandre (Hôpital Claude Huriez) ;
García-Tsao, Guadalupe (Yale University School of Medicine/VA-CT Healthcare System) ;
Roblero, Juan Pablo (Hospital Clínico Universidad de Chile) ;
Abraldes, Juan G. (University of Alberta) ;
Shah, Vijay H. (Mayo Clinic) ;
Kamath, Patrick S. (Mayo Clinic) ;
Arrese, Marco (Pontificia Universidad Católica de Chile) ;
Singal, Ashwani K. (Avera Transplant Institute) ;
Bataller, Ramon (Hospital Clínic i Provincial de Barcelona) ;
Arab, Juan Pablo (Western University) ;
Universitat Autònoma de Barcelona
Model for End-Stage Liver Disease (MELD) score better predicts mortality in alcohol-associated hepatitis (AH) but could underestimate severity in women and malnourished patients. Using a global cohort, we assessed the ability of the MELD 3. [...]
2023 -  10.1016/j.jhepr.2023.100727
JHEP Reports, Vol. 5 (march 2023)
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2.
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23 p, 630.8 KB |
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
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Medina-Cáliz, Inmaculada (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Sanabria-Cabrera, Judith (Instituto de Investigación Biomédica de Málaga) ;
Villanueva-Paz, Marina (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Aukštikalnė, Lauryna (Lithuanian University of Health Sciences) ;
Stephens, Camilla (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Robles-Díaz, Mercedes (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Pinazo-Bandera, José M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
García-Cortes, Miren (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Conde, Isabel (Hospital Universitari I Politècnic La Fe) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
Bessone, Fernando (Hospital Provincial del Centenario) ;
Hernandez, Nelia (Hospital de Clínicas) ;
Nunes, Vinicius (Hospital Universitário Prof. Edgard Santos-UFBA) ;
Paraná, Raymundo (Hospital Universitário Prof. Edgard Santos-UFBA) ;
Lucena, M. Isabel (Universidad de Málaga) ;
Andrade, Raúl J. (Universidad de Málaga) ;
Niu, Hao (Universidad de Málaga) ;
Alvarez-Alvarez, Ismael (Universidad de Málaga) ;
Universitat Autònoma de Barcelona
Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized among patients of Western countries. We aimed to comprehensively assess the clinical characteristics, outcomes, and causative agents in a prospective, well-vetted cohort of DILI patients with DRESS (DILI-DRESS). [...]
2023 - 10.1007/s00204-023-03630-0
Archives of Toxicology, Vol. 98 (december 2023) , p. 303-325
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3.
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8 p, 1.4 MB |
Impact of the COVID-19 pandemic on the incidence and type of infections in hospitalized patients with cirrhosis : a retrospective study
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Cuyàs, Berta (Institut de Recerca Sant Pau) ;
Huerta, Anna (Institut de Recerca Sant Pau) ;
Poca Sans, Maria (Institut de Recerca Sant Pau) ;
Alvarado-Tapias, Edilmar (Institut de Recerca Sant Pau) ;
Brujats Rubirola, Anna (Institut de Recerca Sant Pau) ;
Roman, Eva (Institut de Recerca Sant Pau) ;
Guarner, Carlos (Institut de Recerca Sant Pau) ;
Escorsell, Àngels (Institut de Recerca Sant Pau) ;
Soriano, German (Institut de Recerca Sant Pau) ;
Universitat Autònoma de Barcelona
Infections are a major cause of morbidity and mortality in cirrhosis, especially those caused by multi-drug resistant bacteria. During the COVID-19 pandemic, the incidence and type of infection in these patients may have been influenced by the restrictive measures implemented. [...]
2024 - 10.1038/s41598-024-52452-2
Scientific reports, Vol. 14 (february 2024)
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4.
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14 p, 1.5 MB |
Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis
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Fernández, Javier (Hospital Clínic i Provincial de Barcelona) ;
Clària, J (Hospital Clínic i Provincial de Barcelona) ;
Amorós, Alex (Grifols) ;
Aguilar, Ferran (Grifols) ;
Castro, Miriam (Hospital Clínic i Provincial de Barcelona) ;
Casulleras, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Acevedo, Juan (Derriford Hospital) ;
Duran, Marta (Hospital Clínic i Provincial de Barcelona) ;
Nuñez, Laura (Grifols) ;
Costa, Montserrat (Grifols) ;
Torres, Mireia (Grifols) ;
Horrillo, Raquel (Grifols) ;
Ruiz-del-Árbol, Luis (Hospital Universitario Ramón y Cajal (Madrid)) ;
Villanueva, Càndid (Institut d'Investigació Biomèdica Sant Pau) ;
Prado, Veronica (Hospital Clínic i Provincial de Barcelona) ;
Arteaga, Mireya (Hospital Clínic i Provincial de Barcelona) ;
Trebicka, Jonel (University Hospital of Bonn) ;
Angeli, Paolo (University of Padova) ;
Merli, Manuela (Sapienza University of Rome) ;
Alessandria, Carlo (San Giovanni Battista Hospital) ;
Aagaard, Niels Kristian (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
Durand, Francois (Hopital Beaujon) ;
Gerbes, Alexander L. (LMU Munich) ;
Gustot, Thierry (Erasme Hospital (ULB)) ;
Welzel, Tania M. (Goethe University) ;
Salerno, Francesco (Policlinico IRCCS San Donato) ;
Bañares, Rafael (Hospital General Universitario Gregorio Marañón) ;
Vargas Blasco, Víctor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Albillos, Agustín (Hospital Universitario Ramón y Cajal (Madrid)) ;
Silva, Anibal (Hospital Clínic i Provincial de Barcelona) ;
Morales Ruiz, Manuel (Hospital Clínic i Provincial de Barcelona) ;
García-Pagán, JC. (Hospital Clínic i Provincial de Barcelona) ;
Pavesi, Marco (Grifols) ;
Jalan, Rajiv (Royal Free Hospital) ;
Bernardi, Mauro (University of Bologna) ;
Moreau, Richard (Université Paris Diderot-Paris 7) ;
Páez, Antonio (Grifols) ;
Arroyo, Vicente (Grifols) ;
Universitat Autònoma de Barcelona
We investigated the effect of albumin treatment (20% solution) on hypoalbuminemia, cardiocirculatory dysfunction, portal hypertension, and systemic inflammation in patients with decompensated cirrhosis with and without bacterial infections. [...]
2019 - 10.1053/j.gastro.2019.03.021
Gastroenterology, Vol. 157 Núm. 1 (july 2019) , p. 149-162
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5.
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33 p, 4.3 MB |
Ascitic fluid regulates the local innate immune response of patients with cirrhosis
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Nieto Sáchica, Juan Camilo (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Perea, Lidia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano, German (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Zamora, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Cantó, Elisabet (Institut d'Investigació Biomèdica Sant Pau) ;
Medina Dols, Aina (Institut d'Investigació Biomèdica Sant Pau) ;
Poca Pastor, María Antonia (Hospital Universitari Vall d'Hebron) ;
Sánchez, Elisabet (Instituto de Salud Carlos III) ;
Roman, Eva (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Julià, Germà (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Navarro Risueño, Ferran (Institut d'Investigació Biomèdica Sant Pau) ;
Gely, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Alvarado-Tapias, Edilmar (Institut d'Investigació Biomèdica Sant Pau) ;
Guarner-Argente, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Juarez, Candido (Institut d'Investigació Biomèdica Sant Pau) ;
Vidal, Silvia (Institut d'Investigació Biomèdica Sant Pau)
Ascitic neutrophils from cirrhotic patients with spontaneous bacterial peritonitis (SBP) exhibit an impaired oxidative burst that could facilitate bacterial infection. However, the influence of the cell-free ascitic fluid of these patients on neutrophil function has not been investigated. [...]
2018 - 10.1002/JLB.3A0218-072R
Journal of Leukocyte Biology, Vol. 104, Issue 4 (October 2018) , p. 833-841
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6.
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14 p, 1.0 MB |
The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology
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Trebicka, Jonel (JW Goethe University Hospital) ;
Fernández, Javier (Hospital Clínic i Provincial de Barcelona) ;
Papp, Maria (University of Debrecen) ;
Caraceni, Paolo (University of Bologna) ;
Laleman, Wim (University of Leuven) ;
Gambino, Carmine (University of Padova) ;
Giovo, Ilaria (University of Torino) ;
Uschner, Frank Erhard (JW Goethe University Hospital) ;
Jiménez, Cesar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mookerjee, Rajeshwar Prosad (UCL Royal Free Hospital) ;
Gustot, Thierry (Universite Libre de Bruxelles) ;
Albillos, Agustín (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Bañares, Rafael (Universidad Complutense de Madrid) ;
Janicko, Martin (Pavol Jozef Safarik University in Kosice) ;
Steib, Christian (University Hospital Munich) ;
Reiberger, Thomas (Medical University of Vienna) ;
Acevedo, Juan (University Hospitals Plymouth NHS Trust (Regne Unit)) ;
Gatti, Pietro (Internal Medicine PO Ostuni. ASL Brindisi) ;
Bernal, William (King's College Hospital NHS Foundation Trust) ;
Zeuzem, Stefan (JW Goethe University Hospital) ;
Zipprich, Alexander (University Hospital Halle-Wittenberg) ;
Piano, Salvatore (University of Padova) ;
Berg, Thomas (Leipzig University) ;
Bruns, Tony (Aachen University Hospital) ;
Bendtsen, Flemming (Hvidovre University Hospital) ;
Coenraad, Minneke (Leiden University Medical Center) ;
Merli, Manuela (Universitá Sapienza Roma) ;
Stauber, Rudolf (Medical University of Graz) ;
Zoller, Heinz (Medical University of Innsbruck) ;
Presa Ramos, José (CHTMAD Vila Real) ;
Solé, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
De Gottardi, Andrea (Universita della Svizzera Italiana) ;
Gronbaek, Henning (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Saliba, Faouzi (AP-HP Hôpital Paul Brousse) ;
Trautwein, Christian (Aachen University Hospital) ;
Özdogan, Osman Cavit (Marmara University) ;
Francque, Sven (University Hospital Antwerp) ;
Ryder, Stephen David (University of Nottingham) ;
Nahon, Pierre (AP-HP. Hôpital Jean Verdier) ;
Romero-Gómez, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Van Vlierberghe, Hans (Universitair Ziekenhuis Gent) ;
Francoz, Claire (Université de Paris) ;
Manns, Michael (Hannover Medical School) ;
García López, Elisabet (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Tufoni, Manuel (University of Bologna) ;
Amoros, Alex (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Pavesi, Marco (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Sanchez, Cristina (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Curto, Anna (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Pitarch, Carla (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Putignano, Antonella (Universite Libre de Bruxelles) ;
Moreno, Esau (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Shawcross, Debbie (King's College Hospital NHS Foundation Trust) ;
Aguilar, Ferran (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Clària, J (Hospital Clínic i Provincial de Barcelona) ;
Ponzo, Paola (University of Torino) ;
Jansen, Christian (University Hospital Bonn (Bonn, Alemanya)) ;
Vitalis, Zsuzsanna (University of Debrecen) ;
Zaccherini, Giacomo (University of Bologna) ;
Balogh, Boglarka (University of Debrecen) ;
Vargas Blasco, Víctor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montagnese, Sara (University of Padova) ;
Alessandria, Carlo (University of Torino) ;
Bernardi, Mauro (University of Bologna) ;
Ginès, Pere (Hospital Clínic i Provincial de Barcelona) ;
Jalan, Rajiv (UCL Medical School. Royal Free Hospital) ;
Moreau, Richard (Université de Paris) ;
Angeli, Paolo (University of Padova) ;
Arroyo, Vicente (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Maschmeier, Miriam (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Semela, David (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Elkrief, Laure (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Elsharkawy, Ahmed (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Tornai, Tamás (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Tornai, Istvan (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Altorjay, Istvan (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Antognoli, Agnese (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Baldassarre, Maurizio (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Gagliardi, Martina (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Bertoli, Eleonora (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Mareso, Sara (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Brocca, Alessandra (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Campion, Daniela (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Saracco, Giorgio Maria (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Rizzo, Martina (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Lehmann, Jennifer (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Pohlmann, Alessandra (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Praktiknjo, Michael (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Schierwagen, Robert (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Solà, Elsa (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Amari, Nesrine (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Rodriguez, Miguel (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Nevens, Frederik (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Clemente, Ana (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Jarcuska, Peter (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Gerbes, Alexander L. (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Mandorfer, Mattias (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Welsch, Christoph (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Ciraci, Emanuela (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Patel, Vish (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Ripoll, Cristina (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Herber, Adam (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Horn, Paul (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Danielsen, Karen Vagner (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Gluud, Lise Lotte (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Schaapman, Jelte (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Riggio, Oliviero (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Rainer, Florian (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Moritz, Jörg Tobiasch (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Mesquita, Mónica (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Alvarado-Tapias, Edilmar (Institut d'Investigació Biomèdica Sant Pau) ;
Akpata, Osagie (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Lykke Eriksen, Peter (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Samuel, Didier (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Tresson, Sylvie (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Strnad, Pavel (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Amathieu, Roland (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Simón-Talero, Macarena (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Smits, Francois (PREDICT STUDY group of the EASL-CLIF Consortium) ;
van den Ende, Natalie (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Martinez, Javier (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Garcia, Rita (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Markwardt, Daniel (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Rupprechter, Harald (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Engelmann, Cornelius (PREDICT STUDY group of the EASL-CLIF Consortium) ;
Universitat Autònoma de Barcelona
Acute decompensation (AD) of cirrhosis is defined as the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof, requiring hospitalization. [...]
2020 - 10.1016/j.jhep.2020.06.013
Journal of Hepatology, Vol. 73 Núm. 4 (october 2020) , p. 842-854
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7.
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11 p, 1.2 MB |
Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
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Gil-Gómez, Antonio (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Rojas, Ángela (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
García-Lozano, María R. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Muñoz-Hernández, Rocío (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Gallego-Durán, Rocío (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Maya-Miles, Douglas (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Montero-Vallejo, Rocío (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Gato, Sheila (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Gallego, Javier (Instituto de Biomedicina de Sevilla) ;
Francés, Rubén (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
Ampuero, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Romero-Gómez, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD patients and a reduced risk of progression to advanced fibrosis and cirrhosis. [...]
2022 - 10.3390/ijms231911840
International journal of molecular sciences, Vol. 23 Núm. 19 (october 2022) , p. 11840
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8.
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11 p, 477.7 KB |
Metabolic-associated fatty liver disease : From simple steatosis toward liver cirrhosis and potential complications. Proceedings of the Third Translational Hepatology Meeting, organized by the Spanish Association for the Study of the Liver (AEEH)
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Gallego-Durán, Rocío (SeLiver Group. Instituto de Biomedicina de Sevilla. Consejo Superior de Investigaciones Científicas (Espanya). Universidad de Sevilla) ;
Albillos, Agustín (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Ampuero, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Arechederra, María (Instituto de Investigación Sanitaria de Navarra) ;
Bañares, Rafael (Universidad Complutense de Madrid. Departamento de Medicina) ;
Blas-García, Ana (Universidad de Valencia. Departamento de Fisiología. Facultad de Medicina) ;
Berná, Genoveva (Universidad Pablo de Olavide. Universidad de Sevilla. Consejo Superior de Investigaciones Científicas (Espanya)) ;
Caparrós, Esther (Instituto de Investigación Sanitaria y Biomédica de Alicante. Hospital General de Alicante) ;
Delgado, Teresa C. (Laboratorio de Enfermedades Hepáticas. Centro de Investigación Cooperativa en Biociencias. Alianza Vasca de Investigación y Tecnología) ;
Falcón-Pérez, Juan Manuel (Ikerbasque Fundación Vasca para las Ciencias) ;
Francés, Rubén (Instituto de Investigación Sanitaria y Biomédica de Alicante. Hospital General de Alicante) ;
Fernández-Barrena, Maite G. (Instituto de Investigación Sanitaria de Navarra) ;
Graupera, Isabel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Iruzubieta, Paula (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Nevzorova, Yulia A. (University Hospital RWTH. Department of Internal Medicine III) ;
Nogueiras, Rubén (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Macías, Rocío I.R. (Grupo de Hepatología Experimental y Focalización de Fármacos (HEVEPHARM). Universidad de Salamanca. Instituto de Investigación Biomédica de Salamanca) ;
Martín, Franz (Universidad Pablo de Olavide. Universidad de Sevilla. Consejo Superior de Investigaciones Científicas (Espanya)) ;
Sabio, Guadalupe (Centro Nacional de Investigaciones Cardiovasculares. Fisiopatología miocárdica) ;
Soriano, German (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vaquero, Javier (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Cubero, Francisco Javoer (Universidad Complutense de Madrid. Departamento de Inmunología, Oftalmología y Otorrinolaringología) ;
Gracia-Sancho, Jordi (Department of Visceral Surgery and Medicine. Inselspital. Bern University Hospital. University of Bern)
This is a meeting report of the 3rd Translational Hepatology Meeting held in Alicante, Spain, in October 2021. The meeting, which was organized by the Spanish Association for the Study of the Liver (AEEH), provided an update on the recent advances in the field of basic and translational hepatology, with a particular focus on the molecular and cellular mechanisms and therapeutic targets involved in metabolic-associated fatty liver disease (MAFLD), metabolic-associated steatohepatitis (MASH), cirrhosis and end-stage hepatocellular carcinoma (HCC).
2022 - 10.1016/j.gastrohep.2022.02.005
Gastroenterologia y Hepatologia, Vol. 45 Núm. 9 (november 2022) , p. 724-734
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4 p, 880.1 KB |
A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis : a metabolomic analysis
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Laghi, Luca (University of Bologna) ;
Roman, Eva (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Lan, Qiuyu (University of Bologna) ;
Nieto Sáchica, Juan Camilo (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Canalda-Baltrons, Aleix (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Poca Sans, Maria (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sánchez-Rodríguez, Maria B. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Clària, J (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alvarado-Tapias, Edilmar (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Cuyàs, Berta (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sánchez, Elisabet (Instituto de Salud Carlos III) ;
Vidal, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Guarner, Carlos (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Escorsell, Àngels (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Manichanh, Chaysavanh (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soriano, German (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
To explore the potential mechanisms underlying the effects of a probiotic in cirrhotic patients, we analyzed the blood metabolome using proton nuclear magnetic resonance (1 H-NMR) spectroscopy in 32 patients with cirrhosis and cognitive dysfunction or falls. [...]
2023 - 10.1097/HC9.0000000000000072
Hepatology Communications, Vol. 7 (april 2023)
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PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
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Trebicka, Jonel (Department of Internal Medicine I. Goethe University Frankfurt) ;
Fernández, Javier (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Papp, Maria (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Caraceni, Paolo (University of Bologna) ;
Laleman, Wim (University of Leuven) ;
Gambino, Carmine (University of Padova) ;
Giovo, Ilaria (A.O.U. Città della Salute e della Scienza Torino) ;
Uschner, Frank Erhard (Department of Internal Medicine I. Goethe University Frankfurt) ;
Jansen, Christian (Department of Internal Medicine I. University Hospital Bonn) ;
Jimenez, Cesar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mookerjee, Rajeshwar Prosad (UCL Medical School. Royal Free Hospital) ;
Gustot, Thierry (C.U.B. Erasme) ;
Albillos, Agustín (Hospital Universitario Ramón y Cajal (Madrid)) ;
Bañares, Rafael (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Jarcuska, Peter (Pavol Jozef Safarik University in Kosice) ;
Steib, Christian (Department of Medicine II. Liver Centre Munich. University Hospital. LMU) ;
Reiberger, Thomas (Medical University of Vienna) ;
Acevedo, Juan (University Hospitals Plymouth NHS Trust (Regne Unit)) ;
Gatti, Pietro (Internal Medicine PO Ostuni) ;
Shawcross, Debbie (King's College Hospital NHS Foundation Trust) ;
Zeuzem, Stefan (Department of Internal Medicine I. Goethe University Frankfurt) ;
Zipprich, Alexander (University Hospital Halle-Wittenberg) ;
Piano, Salvatore (University of Padova) ;
Berg, Thomas (Division of Hepatology. Department of Medicine II. Leipzig University. Medical Center) ;
Bruns, Tony (Aachen University Hospital) ;
Danielsen, Karen Vagner (University of Copenhagen) ;
Coenraad, Minneke (Leiden University Medical Center) ;
Merli, Manuela (Universitá Sapienza Roma) ;
Stauber, Rudolf (Medical University of Graz) ;
Zoller, Heinz (Medical University of Innsbruck) ;
Presa Ramos, José (CHTMAD Vila Real-Blueclinical) ;
Solé, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
De Gottardi, Andrea (University Clinic of Visceral Surgery and Medicine-Inselspital. Bern and Ente Ospedaliero Cantonale. Universita della Svizzera Italiana) ;
Gronbaek, Henning (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Saliba, Faouzi (AP-HP Hôpital Paul Brousse. Centre Hépato-Biliaire. Universite Paris Saclay. INSERM Unit 1193) ;
Trautwein, Christian (Aachen University Hospital) ;
Kani, Haluk Tarik (Marmara University) ;
Francque, Sven (University Hospital Antwerp) ;
Ryder, Stephen David (NIHR Biomedical Research Centre at Nottingham University Hospitals NHS Trust and the University of Nottingham) ;
Nahon, Pierre (Inserm. UMR-1162. "Génomique fonctionnelle des tumeurs solides") ;
Romero-Gomez, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Van Vlierberghe, Hans (Universitair Ziekenhuis Gent) ;
Francoz, Claire (Inserm. Université de Paris. Centre de Recherche sur L'Inflammation) ;
Manns, Michael (Hannover Medical School) ;
Garcia-Lopez, Elisabet (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Tufoni, Manuel (University of Bologna) ;
Amoros, Alex (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Pavesi, Marco (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Sanchez, Cristina (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Praktiknjo, Michael (Department of Internal Medicine I. University Hospital Bonn) ;
Curto, Anna (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Pitarch, Carla (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Putignano, Antonella (C.U.B. Erasme) ;
Moreno, Esau (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Bernal, William (King's College Hospital NHS Foundation Trust) ;
Aguilar, Ferran (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Clària, J (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ponzo, Paola (A.O.U. Città della Salute e della Scienza Torino) ;
Vitalis, Zsuzsanna (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Zaccherini, Giacomo (University of Bologna) ;
Balogh, Boglarka (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Gerbes, Alexander L (Department of Medicine II. Liver Centre Munich. University Hospital. LMU) ;
Vargas, Victor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alessandria, Carlo (A.O.U. Città della Salute e della Scienza Torino) ;
Bernardi, Mauro (University of Bologna) ;
Ginès, Pere (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Moreau, Richard (Inserm. Université de Paris. Centre de Recherche sur L'Inflammation) ;
Angeli, Paolo (University of Padova) ;
Jalan, Rajiv (UCL Medical School. Royal Free Hospital) ;
Arroyo, Vicente (European Foundation for Study of Chronic Liver Failure. EF-Clif) ;
Maschmeier, Miriam (Munster University Hospital) ;
Semela, David (University of Basel-St Gall Cantonal Hospital) ;
Elkrief, Laure (Hôpitaux Universitaires de Genève) ;
Elsharkawy, Ahmed (University of Birmingham) ;
Tornai, Tamas (University of Birmingham) ;
Tornai, Istvan (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Altorjay, Istvan (University of Debrecen. Faculty of Medicine. Institute of Medicine. Department of Gastroenterology) ;
Antognoli, Agnese (University of Bologna) ;
Baldassarre, Maurizio (University of Bologna) ;
Gagliardi, Martina (University of Bologna) ;
Bertoli, Eleonora (University of Padova) ;
Mareso, Sara (University of Padova) ;
Brocca, Alessandra (University of Padova) ;
Campion, Daniela (A.O.U. Città della Salute e della Scienza Torino) ;
Saracco, Giorgio Maria (A.O.U. Città della Salute e della Scienza Torino) ;
Rizzo, Martina (A.O.U. Città della Salute e della Scienza Torino) ;
Lehmann, Jennifer (University Hospital Bonn (Bonn, Alemanya)) ;
Pohlmann, Alessandra (University Hospital Bonn (Bonn, Alemanya)) ;
Brol, Maximilian Joseph (University Hospital Bonn (Bonn, Alemanya)) ;
Chang, Johannes (University Hospital Bonn (Bonn, Alemanya)) ;
Schierwagen, Robert (Department of Internal Medicine I. Goethe University Frankfurt) ;
Solà, Elsa (Hospital Clínic i Provincial de Barcelona) ;
Amari, Nesrine (C.U.B. Erasme) ;
Rodriguez, Miguel (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Nevens, Frederik (Department of Gastroenterology and Hepatology. Section of Liver and Biliopancreatic disorders. University of Leuven) ;
Clemente, Ana (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Janicko, Martin (Pavol Jozef Safarik University in Kosice) ;
Markwardt, Daniel (Department of Medicine II. Liver Centre Munich. University Hospital. LMU) ;
Mandorfer, Mattias (Medical University of Vienna) ;
Welsch, Christoph (Department of Internal Medicine I. Goethe University Frankfurt) ;
Welzel, Tanja M. (Department of Internal Medicine I. Goethe University Frankfurt) ;
Ciraci, Emanuela (Internal Medicine PO Ostuni) ;
Patel, Vish (King's College Hospital NHS Foundation Trust) ;
Ripoll, Cristina (University Hospital Halle-Wittenberg) ;
Herber, Aadam (Division of Hepatology. Department of Medicine II. Leipzig University. Medical Center) ;
Horn, Paul (Jena University Hospital (Alemanya)) ;
Bendtsen, Flemming (Gastrounit. Medical Section. Hvidovre Hospital and Department of Clinical Medicine. University of Copenhagen) ;
Gluud, Lise Lotte (Gastrounit. Medical Section. Hvidovre Hospital and Department of Clinical Medicine. University of Copenhagen) ;
Schaapman, Jelte (Leiden University Medical Center) ;
Riggio, Oliviero (Universitá Sapienza Roma) ;
Rainer, Florian (Medical University of Graz) ;
Moritz, Jörg Tobiasch (Medical University of Innsbruck) ;
Mesquita, M. (CHTMAD Vila Real-Blueclinical) ;
Alvarado-Tapias, Edilmar (Institut d'Investigació Biomèdica Sant Pau) ;
Akpata, Osagie (UCL Medical School. Royal Free Hospital) ;
Aamann, Luise (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Samuel, Didier (AP-HP Hôpital Paul Brousse. Centre Hépato-Biliaire. Universite Paris Saclay. INSERM Unit 1193) ;
Tresson, Sylvie (AP-HP Hôpital Paul Brousse. Centre Hépato-Biliaire. Universite Paris Saclay. INSERM Unit 1193) ;
Strnad, Pavel (Aachen University Hospital) ;
Amathieu, Roland (Inserm. UMR-1162. "Génomique fonctionnelle des tumeurs solides") ;
Simón-Talero, Macarena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Smits, Francois (C.U.B. Erasme) ;
van den Ende, Natalie (Department of Gastroenterology and Hepatology. Section of Liver and Biliopancreatic disorders. University of Leuven) ;
Martinez, Javier (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Garcia, Rita (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Rupprechter, Harald (Medical University of Vienna) ;
Engelmann, Cornelius (Division of Hepatology. Department of Medicine II. Leipzig University. Medical Center) ;
Özdogan, Osman Cavit (Marmara University) ;
Universitat Autònoma de Barcelona
Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. [...]
2021 - 10.1016/j.jhep.2020.11.019
Journal of Hepatology, Vol. 74 Núm. 5 (may 2021) , p. 1097-1108
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