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1.
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3 p, 207.7 KB |
In reply : Sex-specific outcomes in COVID-19: missing pieces of the puzzle
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Wolff, Georg (Heinrich-Heine-University Düsseldorf) ;
Wernly, Bernhard (Paracelsus Medical University) ;
Flaatten, Hans (University of Bergen) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bruno, Raphael Romano (Heinrich-Heine-University Düsseldorf) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pinto, Bernardo Bollen (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Kelm, Malte (Heinrich-Heine-University Düsseldorf) ;
Binneboessel, Stephan (Heinrich-Heine-University Düsseldorf) ;
Baldia, Philipp Heinrich (Heinrich-Heine-University Düsseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sivri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Flamm, Maria (Paracelsus Medical University) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Centro Hospitalar Universitário de Lisboa Central) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
De Lange, Dylan W. (University Utrecht) ;
Guidet, Bertrand (Hôpital Saint-Antoine) ;
Leaver, Susannah (St George's University Hospitals NHS Foundation Trust) ;
Jung, Christian (Heinrich-Heine-University Düsseldorf) ;
Universitat Autònoma de Barcelona
2023 -  10.1007/s12630-023-02470-x
Canadian Journal of Anaesthesia, may 2023, p. 1-3
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2.
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9 p, 1.0 MB |
Lactate is associated with mortality in very old intensive care patients suffering from COVID-19 : results from an international observational study of 2860 patients
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Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Wernly, Bernhard (Paracelsus Medical University) ;
Flaatten, Hans (Haukeland University Hospital (Bergen, Noruega)) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Bollen Pinto, Bernardo (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Binnebössel, Stephan (Heinrich-Heine-University Duesseldorf) ;
Baldia, Philipp Heinrich (Heinrich-Heine-University Duesseldorf) ;
Kelm, Malte (Heinrich-Heine-University Duesseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sigal, Sivri (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Zafeiridis, Tilemachos (General University Hospital of Larissa (Grècia)) ;
Wollborn, Jakob (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Arche Banzo, Maria José (Hospital Clínico Universitario Lozano Blesa) ;
Fuest, Kristina (Technical University of Munich) ;
Marsh, Brian (Mater Misericordiae University Hospital) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Centro Hospitalar Universitário de Lisboa Central) ;
Leaver, Susannah (St George'S University Hospitals NHS Foundation Trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
De Lange, Dylan W. (University Utrecht) ;
Guidet, Bertrand (Hôpital Saint-Antoine) ;
Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Universitat Autònoma de Barcelona
Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have been mostly affected during the initial surge in 2020. [...]
2021 - 10.1186/s13613-021-00911-8
Annals of Intensive Care, Vol. 11 (august 2021)
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3.
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12 p, 1.6 MB |
Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe
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Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Wernly, Bernhard (Paracelsus Medical University) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Bollen Pinto, Bernardo (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Wolff, Georg (Heinrich-Heine-University Duesseldorf) ;
Kelm, Malte (Heinrich-Heine-University Duesseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sviri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hadassah University Medical Center) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Czuczwar, Miroslaw (Medical University of Lublin) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Zafeiridis, Tilemachos (General University Hospital of Larissa (Grècia)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Centro Hospitalar Universitário de Lisboa Central) ;
Leaver, Susannah (St George's University Hospital NHS Foundation Trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
De Lange, Dylan W. (University Utrecht) ;
Guidet, Bertrand (Hôpital Saint-Antoine) ;
Flaatten, Hans (University of Bergen) ;
Universitat Autònoma de Barcelona
The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. This was a prospective European observational study (the COVIP study) in ICU patients aged 70 years and older admitted with COVID-19 disease from March to December 2020 to 159 ICUs in 14 European countries. [...]
2021 - 10.1186/s13054-021-03739-7
Critical Care, Vol. 25 (september 2021)
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4.
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10 p, 3.2 MB |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19
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Bruno, Raphael Romano (Heinrich Heine University Düsseldorf) ;
Wernly, Bernhard (Paracelsus Medical University Salzburg) ;
Wolff, Georg (Heinrich Heine University Düsseldorf) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Bollen Pinto, Bernardo (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Kindgen-Milles, Detlef (Heinrich Heine University Düsseldorf) ;
Baldia, Philipp Heinrich (Heinrich Heine University Düsseldorf) ;
Kelm, Malte (Medical Faculty of the Heinrich-Heine University) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sviri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Topeli, Arzu (Hacettepe University Faculty of Medicine) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Kondili, Eumorfia (University Hospital of Heraklion) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Nova Medical School) ;
Leaver, Susannah (St George's University Hospitals NHS Foundation Trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
De Lange, Dylan W. (Utrecht University) ;
Guidet, Bertrand (Hôpital Saint-Antoine) ;
Flaatten, Hans (Haukeland University Hospital (Bergen, Noruega)) ;
Jung, Christian (Heinrich Heine University Düsseldorf) ;
Universitat Autònoma de Barcelona
Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID-19. [...]
2022 - 10.1002/ehf2.13854
ESC Heart Failure, Vol. 9 (march 2022) , p. 1756-1765
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5.
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9 p, 295.2 KB |
Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age-results from the prospective COVIP study
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Wolff, Georg (Heinrich-Heine-University Düsseldorf) ;
Wernly, Bernhard (Paracelsus Medical University) ;
Flaatten, Hans (University of Bergen) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bruno, Raphael Romano (Heinrich-Heine-University Düsseldorf) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pinto, Bernardo Bollen (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Kelm, Malte (Heinrich-Heine-University Düsseldorf) ;
Binneboessel, Stephan (Heinrich-Heine-University Düsseldorf) ;
Baldia, Philipp Heinrich (Heinrich-Heine-University Düsseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sivri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Flamm, Maria (Paracelsus Medical University) ;
Zafeiridis, Tilemachos (General University Hospital of Larissa (Grècia)) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Nova Médical School) ;
Boumendil, Ariane (Sorbonne Universités) ;
De Lange, Dylan W. (University Medical Center) ;
Guidet, Bertrand (Sorbonne Universités) ;
Leaver, Susannah (St George's University Hospitals NHS Foundation Trust) ;
Jung, Christian (Heinrich-Heine-University) ;
Universitat Autònoma de Barcelona
Older critically ill patients with COVID-19 have been the most vulnerable during the ongoing pandemic, with men being more prone to hospitalization and severe disease than women. We aimed to explore sex-specific differences in treatment and outcome after intensive care unit (ICU) admission in this cohort. [...]
2022 - 10.1007/s12630-022-02304-2
Canadian Journal of Anaesthesia, august 2022, p. 1-9
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6.
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9 p, 1.2 MB |
A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems
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Wernly, Bernhard (General Hospital Oberndorf) ;
Flaatten, Hans (Haukeland University Hospital (Bergen, Noruega)) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Fjølner, Jesper (Viborg Regional Hospital) ;
Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pinto, Bernardo Bollen (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Kelm, Malte (Heinrich-Heine-University Duesseldorf) ;
Sigal, Sviri (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Rezar, Richard (Paracelsus Medical University of Salzburg) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Wolff, Georg (Heinrich-Heine-University Duesseldorf) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Universidade da Beira Interior) ;
Wernly, Sarah (General Hospital Oberndorf) ;
Leaver, Susannah (St. George's University Hospital NHS Foundation Trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine (França)) ;
De Lange, Dylan W. (University Utrecht) ;
Guidet, Bertrand (Hôpital Saint-Antoine (França)) ;
Perings, Stefan (Heinrich-Heine-University Duesseldorf) ;
Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Universitat Autònoma de Barcelona
In Europe, tax-based healthcare systems (THS) and social health insurance systems (SHI) coexist. We examined differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in intensive care units in a THS or SHI. [...]
2022 - 10.1038/s41598-022-21580-y
Scientific reports, Vol. 12 (october 2022)
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7.
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9 p, 930.0 KB |
Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients : a multicenter prospective observational cohort study
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Mayerhöfer, Timo (Medical University Innsbruck) ;
Klein, Sebastian (Medical University Innsbruck) ;
Wernly, Bernhard (Paracelsus Medical University of Salzburg) ;
Flaatten, Hans (Haukeland University Hospital (Noruega)) ;
Guidet, Bertrand (Assistance Publique-Hôpitaux de Paris) ;
De Lange, Dylan W. (University Utrecht) ;
Fjølner, Jesper (Viborg Regional Hospital) ;
Leaver, Susannah (St George's Hospital) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sviri, Sigal (Hebrew University of Jerusalem) ;
Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Pinto, Bernardo Bollen (Geneva University Hospitals (Suïssa)) ;
Schefold, Joerg C. (Bern University Hospital) ;
Moreno, Rui (UCentro Hospitalar Universitário de Lisboa Central) ;
Cecconi, Maurizio (Humanitas University (Itàlia)) ;
Szczeklik, Wojciech (Jagiellonian University Medical College Center for Intensive Care and Perioperative Medicine) ;
Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Joannidis, Michael (Medical University Innsbruck) ;
Universitat Autònoma de Barcelona
Several studies have found an association between diabetes mellitus, disease severity and outcome in COVID-19 patients. Old critically ill patients are particularly at risk. This study aimed to investigate the impact of diabetes mellitus on 90-day mortality in a high-risk cohort of critically ill patients over 70 years of age. [...]
2023 - 10.1007/s15010-023-02001-2
Infection, march 2023, p. 1-9
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11 p, 2.2 MB |
The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
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Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Wernly, Bernhard (Paracelsus Medical University Salzburg) ;
Flaatten, Hans (University of Bergen) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Baldia, Philipp Heinrich (Heinrich-Heine-University Duesseldorf) ;
Binneboessel, Stephan (Heinrich-Heine-University Duesseldorf) ;
Bollen Pinto, Bernardo (Geneva University Hospitals (Suïssa)) ;
Schefold, Joerg C. (University of Bern) ;
Wolff, Georg (Heinrich-Heine-University Duesseldorf) ;
Kelm, Malte (Heinrich-Heine-University Duesseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sviri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Kondili, Eumorfia (University Hospital of Heraklion. Intensive Care Unit) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Wollborn, Jakob (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Universidade da Beira Interior) ;
Leaver, Susannah (St George'S University Hospitals NHS Foundation Trust) ;
Boumendil, Ariane (Sorbonne Universités) ;
De Lange, Dylan W.. (University Utrecht) ;
Guidet, Bertrand (Hôpital Saint-Antoine (França)) ;
Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Universitat Autònoma de Barcelona
Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities of Daily Living (ADL) with the outcome in this vulnerable patient group. [...]
2022 - 10.1186/s13613-022-00996-9
Annals of Intensive Care, Vol. 12 (march 2022)
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9.
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9 p, 1.2 MB |
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU : a prospective cohort study
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Fronczek, Jakub (Jagiellonian University Medical College) ;
Polok, Kamil (Jagiellonian University Medical College) ;
De Lange, Dylan W.. (University Utrecht) ;
Jung, Christian (University Hospital of Düsseldorf (Alemanya)) ;
Beil, Michael (Hadassah Medical Center. Medical Intensive Care Unit) ;
Rhodes, Andrew (St George's University Hospitals NHS Foundation Trust) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Górka, Jacek (Jagiellonian University Medical College) ;
Andersen, Finn H. (Ålesund Hospital) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Cecconi, Maurizio (Humanitas University (Alemanya)) ;
Christensen, Steffen (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Joannidis, Michael (Medical University Innsbruck) ;
Leaver, Susannah (Research Lead Critical Care Directorate St George's Hospital) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Morandi, Alessandro (Hospital Ancelle di Cremona Italy) ;
Moreno, Rui (Centro Hospitalar Universitário de Lisboa Central) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Agvald-Öhman, Christina (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Bollen Pinto, Bernardo (Geneva University Hospitals (Suïssa)) ;
Schefold, Joerg C. (Bern University Hospital) ;
Valentin, Andreas (Kardinal Schwarzenberg Hospital (Àustria)) ;
Walther, Sten (Linköping University) ;
Watson, Ximena (St George's University Hospitals NHS Foundation Trust) ;
Zafeiridis, Tilemachos (General University Hospital of Larissa (Grècia)) ;
Sviri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Flaatten, Hans (University of Bergen) ;
Guidet, Bertrand (Institut Pierre Louis d'Epidémiologie et de Santé Publique) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Universitat Autònoma de Barcelona
The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. [...]
2021 - 10.1186/s13054-021-03632-3
Critical Care, Vol. 25 (july 2021)
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10.
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9 p, 614.7 KB |
Steroid use in elderly critically ill COVID-19 patients
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Jung, Christian (Heinrich-Heine-University Duesseldorf) ;
Wernly, Bernhard (Paracelsus Medical University) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bruno, Raphael Romano (Heinrich-Heine-University Duesseldorf) ;
Dudzinski, David (Massachusetts General Hospital (Boston)) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pinto, Bernardo Bollen (Geneva University Hospitals (Suïssa)) ;
Schefold, Joerg C. (University of Bern) ;
Wolff, Georg (Heinrich-Heine-University Duesseldorf) ;
Kelm, Malte (Heinrich-Heine-University Duesseldorf) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sigal, Sviri (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Czuczwar, Miroslaw (Medical University of Lublin) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Ghent University Hospital (Bèlgica)) ;
Zafeiridis, Tilemachos (General University Hospital of Larissa (Grècia)) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian university of Science and Technology) ;
Moreno, Rui (Centro Hospitalar Universitário de Lisboa Central) ;
Cecconi, Maurizio (Humanitas University (Itàlia)) ;
Leaver, Susannah (St Georgés University Hospitals NHS Foundation trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine (França)) ;
De Lange, Dylan W.. (University Utrecht) ;
Guidet, Bertrand (Hôpitaux de Paris) ;
Flaatten, Hans (Haukeland University Hospital (Noruega)) ;
Universitat Autònoma de Barcelona
More than a year after the onset of the SARS-Cov-2 pandemic, treating patients with COVID-19 remains a challenge. By contrast to the rapid development of effective vaccines against SARS-Cov-2, the development of specific and effective therapeutics against COVID-19 remains largely unresolved. [...]
2021 - 10.1183/13993003.00979-2021
European respiratory journal, june 2021
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