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20 p, 1.1 MB |
RHOA Therapeutic Targeting in Hematological Cancers
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Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez Vinces, Salvador (Sao Francisco University Medical School, São Paulo, Brazil) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Primarily identified as an important regulator of cytoskeletal dynamics, the small GTPase Ras homolog gene family member A (RHOA) has been implicated in the transduction of signals regulating a broad range of cellular functions such as cell survival, migration, adhesion and proliferation. [...]
2023 -  10.3390/cells12030433
Cells, Vol. 12 Núm. 3 (february 2023) , p. 433
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13 p, 3.5 MB |
Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations
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Álvarez Pérez, Iñaki (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tirado-Herranz, Adrián (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Alvarez-Palomo, Belén (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Osete, Jordi Requena (Oslo University Hospital (Oslo, Noruega)) ;
Edel, Michael J (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Background: Proteins targeted by the ubiquitin proteasome system (UPS) are identified for degradation by the proteasome, which has been implicated in the development of neurodegenerative diseases. Major histocompatibility complex (MHC) molecules present peptides broken down by the proteasome and are involved in neuronal plasticity, regulating the synapse number and axon regeneration in the central or peripheral nervous system during development and in brain diseases. [...]
2023 - 10.3390/cells12242800
Cells, Vol. 12 (december 2023)
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17 p, 2.9 MB |
The E1a Adenoviral Gene Upregulates the Yamanaka Factors to Induce Partial Cellular Reprogramming
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Mendoza, Gracia (Instituto de Investigación Sanitaria de Aragón) ;
González-Pastor, Rebeca (Universidad UTE. Centro de Investigación Biomédica) ;
Sánchez, Juan Miguel (Imperial College London. National Heart and Lung Institute) ;
Arce Cerezo, Altamira (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Quintanilla, Miguel (Universidad Autónoma de Madrid. Departamento de Bioquímica) ;
Moreno-Bueno, Gema (Instituto de Salud Carlos III. Centro de Investigación Biomédica en Red) ;
Pujol i Altarriba, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Belmar-López, Carolina (Universidad Privada San Juan Bautista) ;
de Martino, Alba (Instituto de Investigación Sanitaria de Aragón) ;
Riu, Efrén (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Rodriguez, Tristan A. (Imperial College London. National Heart and Lung Institute) ;
Martin-Duque, Pilar (Universidad de Zaragoza. Departamento de Cirugía)
The induction of pluripotency by enforced expression of different sets of genes in somatic cells has been achieved with reprogramming technologies first described by Yamanaka's group. Methodologies for generating induced pluripotent stem cells are as varied as the combinations of genes used. [...]
2023 - 10.3390/cells12091338
Cells, Vol. 12 (may 2023)
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14 p, 3.9 MB |
Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis †
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González-Ramos, Silvia (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Fernández-García, V. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Recalde, Miriam (Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM)) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ;
Andrés, Vicente (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Martín-Sanz, Paloma (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Boscá, Lisardo (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Universitat Autònoma de Barcelona
Atherothrombosis, the main cause of acute coronary syndromes (ACS), is characterized by the rupture of the atherosclerotic plaque followed by the formation of thrombi. Fatal plaque rupture sites show large necrotic cores combined with high levels of inflammation and thin layers of collagen. [...]
2020 - 10.3390/cells9092067
Cells, Vol. 9 Núm. 9 (october 2020) , p. 632
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17 p, 2.1 MB |
LRP1-Mediated AggLDL Endocytosis Promotes Cholesteryl Ester Accumulation and Impairs Insulin Response in HL-1 Cells
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Actis Dato, Virginia (Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI)) ;
Benitez Amaro, Aleyda (Institut d'Investigació Biomèdica Sant Pau) ;
Gonzalo Calvo, David de (Instituto de Salud Carlos III) ;
Vazquez, M. (Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI)) ;
Bonacci, G. (Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI)) ;
Llorente-Cortés, V. (Instituto de Salud Carlos III) ;
Chiabrando, G.A. (Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI)) ;
Universitat Autònoma de Barcelona
The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated LDL (aggLDL) internalization is mediated by low-density lipoprotein receptor-related protein-1 (LRP1) promoting intracellular cholesteryl ester (CE) accumulation. [...]
2020 - 10.3390/cells9010182
Cells, Vol. 9 Núm. 1 (october 2020) , p. 419
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10 p, 3.5 MB |
Compliance in Non-Clinical Development of Cell-, Gene-, and Tissue-Based Medicines : Good Practice for Better Therapies
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Lopez-Navas, Luís (Andalusian Network for the Design and Translation of Advanced Therapies. Andalusian Health Ministry) ;
Torrents, Sílvia (Banc de Sang i Teixits. Edifici Dr. Frederic Duran i Jordà) ;
Sánchez-Pernaute, Rosario (Andalusian Network for the Design and Translation of Advanced Therapies. Andalusian Health Ministry) ;
Vives, Joaquin (Universitat Autònoma de Barcelona. Departament de Medicina)
The development of cell-, gene-and tissue engineering (CGT)-based therapies must adhere to strict pharmaceutical quality management standards, as for any other biological or small-molecule drug. However, early developments often failed to fully comply with good laboratory practices (GLP) in non-clinical safety studies. [...]
2022 - 10.1093/stcltm/szac046
Stem Cells Translational Medicine, Vol. 11 Núm. 8 (august 2022) , p. 805-813
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13 p, 1.6 MB |
Identification of Unique microRNA Profiles in Different Types of Idiopathic Inflammatory Myopathy
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Muñoz-Braceras, Sandra (National Institutes of Health (Estats Units d'Amèrica)) ;
Pinal-Fernandez, Iago (Johns Hopkins University School of Medicine) ;
Casal-Dominguez, Maria (Johns Hopkins University School of Medicine) ;
Pak, Katherine (National Institutes of Health (Estats Units d'Amèrica)) ;
Milisenda, José César (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lu, Shajia (National Institutes of Health (Estats Units d'Amèrica)) ;
Gadina, Massimo (National Institutes of Health (Estats Units d'Amèrica)) ;
Naz, Faiza (National Institutes of Health (Estats Units d'Amèrica)) ;
Gutierrez-Cruz, Gustavo (National Institutes of Health (Estats Units d'Amèrica)) ;
Dell'Orso, Stefania (National Institutes of Health (Estats Units d'Amèrica)) ;
Torres-Ruiz, Jiram (Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Mèxic)) ;
Grau-Junyent, Josep Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Selva O'Callaghan, Albert (Hospital Universitari Vall d'Hebron) ;
Paik, Julie J. (Johns Hopkins University School of Medicine) ;
Albayda, Jemima (Johns Hopkins University School of Medicine) ;
Christopher-Stine, Lisa (Johns Hopkins University School of Medicine) ;
Lloyd, Thomas E. (Johns Hopkins University School of Medicine) ;
Corse, Andrea (Johns Hopkins University School of Medicine) ;
Mammen, Andrew L. (Johns Hopkins University School of Medicine) ;
Universitat Autònoma de Barcelona
Dermatomyositis (DM), antisynthetase syndrome (AS), immune-mediated necrotizing myopathy (IMNM), and inclusion body myositis (IBM) are four major types of idiopathic inflammatory myopathy (IIM). Muscle biopsies from each type of IIM have unique transcriptomic profiles. [...]
2023 - 10.3390/cells12172198
Cells, Vol. 12 (september 2023)
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19 p, 5.8 MB |
Deep Learning Analyses to Delineate the Molecular Remodeling Process after Myocardial Infarction
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Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rudilla, F (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer-Curriu, Gemma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Segú-Vergés, Cristina (Anaxomics Biotech S.L.) ;
Mellado-Bergillos, Araceli (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gomez-Puchades, Pol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Specific proteins and processes have been identified in post-myocardial infarction (MI) pathological remodeling, but a comprehensive understanding of the complete molecular evolution is lacking. We generated microarray data from swine heart biopsies at baseline and 6, 30, and 45 days after infarction to feed machine-learning algorithms. [...]
2021 - 10.3390/cells10123268
Cells, Vol. 10 (november 2021)
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